Table 3

Effect of peri-biopsy corticosteroid therapy

PrebiopsyPostbiopsyP values*P values
Without IM or IA steroid
US-NB (n=321)
 Pain (mean (SD))53.6 (28.9)41.4 (30.4)<0.001<0.001
 Stiffness (mean (SD))51.9 (30.4)39.4 (30.8)<0.001<0.001
 Swelling (mean (SD))50.9 (30.9)38.2 (30.1)<0.001<0.001
US-P&F (n=62)
 Pain (mean (SD))43.7 (32.5)31.6 (27.2)0.0030.005
 Stiffness (mean (SD))45.5 (33.7)33.4 (27.6)0.0030.006
 Swelling (mean (SD))39.3 (32.7)30.7 (26.4)0.0210.029
AGSB (n=41)
 Pain (mean (SD))62.3 (23.5)49.3 (22.4)0.0170.001
 Stiffness (mean (SD))45.4 (31.5)38 (26.6)0.2960.001
 Swelling (mean (SD))49.6 (30.9)41.7 (28.2)0.198<0.001
With IM or IA steroid
US-NB (n=81)
 Pain (mean (SD))46.3 (29.4)31.8 (26.9)0.001<0.001
 Stiffness (mean (SD))49.8 (30.1)31.2 (28.2)<0.0010.001
 Swelling (mean (SD))47.8 (29.9)27.3 (27.7)<0.001<0.001
US-P&F (n=3)
 Pain (mean (SD))84.7 (7.2)49.3 (33.5)0.1730.279
 Stiffness (mean (SD))83.7 (8.1)40.7 (42.4)0.1920.304
 Swelling (mean (SD))76 (21.3)42 (36)0.1890.300
AGSB (n=16)
 Pain (mean (SD))62.9 (26)28.9 (16.1)<0.001<0.001
 Stiffness (mean (SD))57.5 (25.2)31.8 (20.4)<0.001<0.001
 Swelling (mean (SD))61.9 (23.0)24.2 (14.2)<0.001<0.001
  • *P value by unadjusted cluster linear regression.

  • †Here adjusted for disease activity and pre-PRO value.

  • AGSB, arthroscopic-guided synovial biopsy; IA, intra-articular; IM, intramuscular; US-NB, ultrasound-guided needle biopsy; US-P&F, ultrasound-guided portal and forceps.