0–3 months | 0–6 months | |||
Change mean±SD | SRM (95% CI) | Change mean±SD | SRM (95% CI) | |
Disease Activity Score | −1.71±1.04 | −1.63 (−1.89 to −1.42) | −1.95±1.09 | −1.80 (−2.04 to −1.60) |
Physician global assessment VAS | −26.2±19.2 | −1.37 (−1.54 to −1.22) | 29.2±20.7 | −1.41 (−1.58 to −1.27) |
Swollen joints* | −8.86±6.89 | −1.28 (−1.46 to −1.14) | −9.63±7.41 | −1.30 (−1.46 to −1.17) |
Patient global assessment VAS | −28.3±24.2 | −1.17 (−1.35 to −1.02) | −30.2±25.2 | −1.20 (−1.38 to −1.05) |
PROMIS physical function | 9.14±7.91 | 1.16 (1.01 to 1.32) | 9.98±8.48 | 1.18 (1.02 to 1.36) |
Joint pain VAS | −27.7±24.4 | −1.14 (−1.31 to −0.98) | −29.5±25.2 | −1.17 (−1.35 to −1.02) |
RAID | −2.25±1.98 | −1.13 (−1.33 to −0.96) | −2.39±1.98 | −1.21 (−1.38 to −1.06) |
SF-36 physical component summary | 8.99±9.02 | 1.00 (0.84 to 1.18) | 9.19±9.47 | 0.97 (0.83 to 1.14) |
Tender joints† | −5.75±6.03 | −0.95 (−1.12 to −0.80) | −6.33±6.30 | −1.01 (−1.15 to −0.88) |
Erythrocyte sedimentation rate | −10.9±15.0 | −0.73 (−0.83 to −0.63) | −11.7±16.5 | −0.71 (−0.84 to −0.59) |
C reactive protein | −9.68±18.4 | −0.53 (−0.62 to −0.43) | −10.8±19.5 | −0.55 (−0.63 to −0.48) |
Fatigue VAS | −13.3±29.3 | −0.45 (−0.60 to −0.32) | −16.0±29.8 | −0.54 (−0.68 to −0.40) |
SF-36 mental component summary | 3.89±10.6 | 0.37 (0.23 to 0.52) | 3.02±10.8 | 0.28 (0.15 to 0.43) |
*Assessment of 44 joints (0–44).
†Ritchie Articular Index (0–78).
RAID, Rheumatoid Arthritis Impact of Disease (0–10);VAS, Visual Analogue Scale (mm, 0–100);PROMIS, Patient-Reported Outcome Information System (20–100);SF-36, 36-item Short Form Health Survey (0–100).