Table 2

Mean change±SD and standardised response mean (SRM) with 95% CIs for patient-reported outcomes and conventional disease activity measures from baseline to 3 months and from baseline to 6 months ordered by decreasing SRM at 3 months

0–3 months0–6 months
Change mean±SDSRM
(95% CI)
Change mean±SDSRM
(95% CI)
Disease Activity Score−1.71±1.04−1.63 (−1.89 to −1.42)−1.95±1.09−1.80 (−2.04 to −1.60)
Physician global assessment VAS−26.2±19.2−1.37 (−1.54 to −1.22)29.2±20.7−1.41 (−1.58 to −1.27)
Swollen joints*−8.86±6.89−1.28 (−1.46 to −1.14)−9.63±7.41−1.30 (−1.46 to −1.17)
Patient global assessment VAS−28.3±24.2−1.17 (−1.35 to −1.02)−30.2±25.2−1.20 (−1.38 to −1.05)
PROMIS physical function9.14±7.911.16 (1.01 to 1.32)9.98±8.481.18 (1.02 to 1.36)
Joint pain VAS−27.7±24.4−1.14 (−1.31 to −0.98)−29.5±25.2−1.17 (−1.35 to −1.02)
RAID−2.25±1.98−1.13 (−1.33 to −0.96)−2.39±1.98−1.21 (−1.38 to −1.06)
SF-36 physical component summary8.99±9.021.00 (0.84 to 1.18)9.19±9.470.97 (0.83 to 1.14)
Tender joints†−5.75±6.03−0.95 (−1.12 to −0.80)−6.33±6.30−1.01 (−1.15 to −0.88)
Erythrocyte sedimentation rate−10.9±15.0−0.73 (−0.83 to −0.63)−11.7±16.5−0.71 (−0.84 to −0.59)
C reactive protein−9.68±18.4−0.53 (−0.62 to −0.43)−10.8±19.5−0.55 (−0.63 to −0.48)
Fatigue VAS−13.3±29.3−0.45 (−0.60 to −0.32)−16.0±29.8−0.54 (−0.68 to −0.40)
SF-36 mental component summary3.89±10.60.37 (0.23 to 0.52)3.02±10.80.28 (0.15 to 0.43)
  • *Assessment of 44 joints (0–44).

  • †Ritchie Articular Index (0–78).

  • RAID, Rheumatoid Arthritis Impact of Disease (0–10);VAS, Visual Analogue Scale (mm, 0–100);PROMIS, Patient-Reported Outcome Information System (20–100);SF-36, 36-item Short Form Health Survey (0–100).