Table 4

Association between ACPA/RF status at baseline and CDAI components over time as using GLMMs

Regression coefficients (standard error), p-value
Adjusted models
SJC-28TJC-28PtGAPhGA
ACPA status at baseline
ACPA neg/RF negRefRefRefRef
ACPA neg /RF pos−0.04 (0.22), 0.84−0.09 (0.31), 0.770.18 (0.18), 0.310.12 (0.17), 0.50
ACPA pos /RF neg−0.003 (0.28), 0.99−0.43 (0.39), 0.28−0.06 (0.23), 0.79−0.03 (0.21), 0.90
ACPA pos /RF pos−0.18 (0.15), 0.22−0.65 (0.21), 0.002−0.48 (0.12), 0.0001−0.29 (0.11), 0.01
Time (month)−0.04 (0.001),<0.0001−0.05 (0.001),<0.0001−0.02 (0.001),<0.0001−0.03 (0.001),<0.0001
Female0.58 (0.15), 0.00020.85 (0.22),<0.00010.19 (0.13), 0.130.14 (0.12), 0.23
Age at baseline0.001 (0.005), 0.79−0.01 (0.01), 0.07−0.001 (0.004), 0.75−0.01 (0.004), 0.07
SJC-28 at baseline0.34 (0.01),<0.0001
TJC-28 at baseline0.41 (0.01),<0.0001
PtGA at baseline0.43 (0.02),<0.0001
PhGA at baseline0.42 (0.02),<0.0001
  • Adjusted model is adjusted for age, sex, time and relevant disease activity measures at baseline.

  • Bold values indicate statistically significant.

  • ACPA, anticitrullinated protein antibody; CDAI, Clinical Disease Activity Index; GLMMs, Generalised Linear Mixed Models; PhGA, physician global assessment; PtGA, patient global assessment; RF, rheumatoid factor; SJC-28, 28-joint swollen count; TCJ-28, 28-joint tender count.