Association between ACPA/RF status at baseline and CDAI components over time as using GLMMs
| Regression coefficients (standard error), p-value | ||||
| Adjusted models | ||||
| SJC-28 | TJC-28 | PtGA | PhGA | |
| ACPA status at baseline | ||||
| ACPA neg/RF neg | Ref | Ref | Ref | Ref |
| ACPA neg /RF pos | −0.04 (0.22), 0.84 | −0.09 (0.31), 0.77 | 0.18 (0.18), 0.31 | 0.12 (0.17), 0.50 |
| ACPA pos /RF neg | −0.003 (0.28), 0.99 | −0.43 (0.39), 0.28 | −0.06 (0.23), 0.79 | −0.03 (0.21), 0.90 |
| ACPA pos /RF pos | −0.18 (0.15), 0.22 | −0.65 (0.21), 0.002 | −0.48 (0.12), 0.0001 | −0.29 (0.11), 0.01 |
| Time (month) | −0.04 (0.001),<0.0001 | −0.05 (0.001),<0.0001 | −0.02 (0.001),<0.0001 | −0.03 (0.001),<0.0001 |
| Female | 0.58 (0.15), 0.0002 | 0.85 (0.22),<0.0001 | 0.19 (0.13), 0.13 | 0.14 (0.12), 0.23 |
| Age at baseline | 0.001 (0.005), 0.79 | −0.01 (0.01), 0.07 | −0.001 (0.004), 0.75 | −0.01 (0.004), 0.07 |
| SJC-28 at baseline | 0.34 (0.01),<0.0001 | – | – | – |
| TJC-28 at baseline | – | 0.41 (0.01),<0.0001 | – | – |
| PtGA at baseline | – | – | 0.43 (0.02),<0.0001 | – |
| PhGA at baseline | – | – | – | 0.42 (0.02),<0.0001 |
Adjusted model is adjusted for age, sex, time and relevant disease activity measures at baseline.
Bold values indicate statistically significant.
ACPA, anticitrullinated protein antibody; CDAI, Clinical Disease Activity Index; GLMMs, Generalised Linear Mixed Models; PhGA, physician global assessment; PtGA, patient global assessment; RF, rheumatoid factor; SJC-28, 28-joint swollen count; TCJ-28, 28-joint tender count.