Inhibitors targeting BET proteins have been tested in animal models resembling diverse characteristic of rheumatic diseases
| Animal model | Inhibitor | Administration | References |
| A rthritis | |||
| CIA (mouse) | JQ1 | intraperitoneal | Mele et al 34 |
| CIA (mouse) | JQ1 | n.d. | Zhang et al 67 |
| CIA (mouse) | JQ1 | intraperitoneal | Xiao et al 60 |
| CAIA (mouse) | RVX-297 | oral | Jahagirdar et al 37 |
| CIA (mouse, rat) | RVX-297 | oral | Jahagirdar et al 37 |
| K/BxN serum transfer (mouse) | I-BET151 | intraperitoneal | Park-Min et al 55 |
| O steoporosis | |||
| OVX (mouse) | I-BET151 | intraperitoneal | Park-Min et al 55 |
| Osteoarthritis | |||
| DMM (mouse) | I-BET151 | intraperitoneal | Dai et al 62 |
| S ystemic lupus erythematosus | |||
| MRL-lpr (mouse) | JQ1 | oral | Wei et al 36 |
| P soriasis | |||
| IMQ (mouse) | JQ1 | topical | Nadeem et al 77 |
| A nkylosing spondylitis | |||
| HLA-B27/β2m (rat) | I-BET151 | intraperitoneal | Fan et al 82 |
| F ibrosis | |||
| Bleomycin (mouse) | JQ1 | oral (chow) | Tang et al 85 |
| Bleomycin (mouse) | JQ1 | oral (chow) | Tang et al 22 |
| UUO (mouse) | I-BET151 | intraperitoneal | Xiong et al 23 |
| TAD (mouse) | JQ1 | intraperitoneal | Duan et al 20 |
| LAD (mouse) | JQ1 | intraperitoneal | Duan et al 20 |
| CCl4 (mouse) | JQ1 | intraperitoneal | Ding et al 19 |
BET, bromodomain and extra-terminal; CAIA, collagen antibody induced arthritis; CCl4, carbon tetrachloride; CIA, collagen-induced arthritis; DMM, destabilisation of the medial meniscus; HLA, human leucocyte antigen; IMQ, imiquimod; LAD, left anterior descending; n.d., not defined; OVX, ovariectomy; TAD, transverse aortic constriction; UUO, unilateral ureteral obstruction.