Linearmixedmodel | Estimate | SE | P values |
Intercept | |||
Class 1 | 5.2433 | 0.6394 | <0.0001 |
Class 2 | 5.7507 | 0.2552 | <0.0001 |
Class 3 | 5.8371 | 0.2018 | <0.0001 |
Ethnicity | |||
White versus rest: class 1 | –0.1746 | 0.1929 | 0.3655 |
White versus rest: class 2 | –0.2380 | 0.1034 | 0.0213 |
White versus rest: class 3 | –0.1233 | 0.0931 | 0.1852 |
Follow-up time in study, weeks | |||
Class 1 | –0.1668 | 0.0091 | <0.0001 |
Class 2 | –0.0863 | 0.0059 | <0.0001 |
Class 3 | –0.0030 | 0.0042 | 0.4697 |
Follow-up time squared | |||
Class 1 | 0.0021 | 0.0001 | <0.0001 |
Class 2 | 0.0014 | 0.0001 | <0.0001 |
Class 3 | 0.0001 | 0.0001 | 0.1708 |
MTX use | |||
(Randomised MTX, previous on) versus previous on but not randomised: class 1 | 1.0513 | 0.6129 | 0.0863 |
(Randomised MTX, previous on) versus previous on, but not randomised: class 2 | 0.0186 | 0.2750 | 0.9461 |
(Randomised MTX, previous on) versus previous on, but not randomised: class 3 | 0.3206 | 0.2381 | 0.1781 |
Background MTX continued versus previous on but not randomised: class 1 | 0.9683 | 0.6140 | 0.1148 |
Background MTX continued versus previous on but not randomised: class 2 | 0.0762 | 0.2430 | 0.7539 |
Background MTX continued versus previous on but not randomised: class 3 | 0.5088 | 0.1729 | 0.0032 |
Randomised or on csDMARD at start | |||
Yes versus no: class 1 | 0.5336 | 0.6840 | 0.4353 |
Yes versus no: class 2 | –0.1657 | 0.3004 | 0.5813 |
Yes versus no: class 3 | 0.6739 | 0.2151 | 0.0017 |
On background glucocorticoids at start | |||
Yes versus no: class 1 | –0.1578 | 0.1551 | 0.3088 |
Yes versus no: class 2 | 0.0648 | 0.0843 | 0.4419 |
Yes versus no: class 3 | –0.1037 | 0.0788 | 0.1885 |
HAQ (time varying) | |||
Class 1 | 0.3958 | 0.0601 | <0.0001 |
Class 2 | 0.3773 | 0.0413 | <0.0001 |
Class 3 | 0.2641 | 0.0313 | <0.0001 |
Variance components* | |||
Variance of random intercept | 0.6174 | 0.0269 | <0.0001 |
Error SD | 0.6902 | 0.0056 | <0.0001 |
Relative entropy† | 0.609 |
*Trial-level random effects were investigated and found to be not necessary.
†A relative entropy takes values between 0 and 1, with 1 indicating perfect classification.
csDMARD, conventional synthetic disease-modifying antirheumatic drug; HAQ, HealthAssessment Questionnaire; MTX, methotrexate.