OR with 95% CI of developing ACPA-positive and ACPA-negative RA for overweight and obese women compared with normal weight women stratified by smoking habits
| ACPA-positive RA | ACPA-negative RA | |||
| BMI | Ca/Co* | Ca/Co* | Ca/Co* | OR (95% CI)† |
| Never smokers | ||||
| Normal weight | 327/1089 | 1.0 (reference) | 186/1089 | 1.0 (reference) |
| Overweight | 156/541 | 1.0 (0.8–1.3) | 98/541 | 1.1 (0.8–1.4) |
| Obesity | 71/268 | 1.0 (0.7–1.3) | 55/268 | 1.3 (0.9–1.8) |
| P for trend | 0.8 | 0.8 | ||
| Ever-smokers | ||||
| Normal weight | 617/1337 | 1.0 (reference) | 257/1337 | 1.0 (reference) |
| Overweight | 350/655 | 1.2 (1.0–1.4) | 163/655 | 1.3 (1.0–1.6) |
| Obesity | 171/232 | 1.6 (1.3–2.0) | 96/232 | 2.1 (1.6–2.8) |
| P for trend | <0.0001 | <0.0001 | ||
*Number of exposed cases and controls.
†Adjusted for age, gender, residential area, ancestry and study.
ACPA, anticitrullinated peptide antibody; BMI, body mass index; RA, rheumatoid arthritis.