Table 3

OR with 95% CI of developing ACPA-positive and ACPA-negative RA for overweight and obese women compared with normal weight women stratified by smoking habits

ACPA-positive RAACPA-negative RA
BMICa/Co*Ca/Co*Ca/Co*OR (95% CI)†
Never smokers
Normal weight327/10891.0 (reference)186/10891.0 (reference)
Overweight156/5411.0 (0.8–1.3)98/5411.1 (0.8–1.4)
Obesity71/2681.0 (0.7–1.3)55/2681.3 (0.9–1.8)
P for trend0.80.8
Normal weight617/13371.0 (reference)257/13371.0 (reference)
Overweight350/6551.2 (1.0–1.4)163/6551.3 (1.0–1.6)
Obesity171/2321.6 (1.3–2.0)96/2322.1 (1.6–2.8)
P for trend<0.0001<0.0001
  • *Number of exposed cases and controls.

  • †Adjusted for age, gender, residential area, ancestry and study.

  • ACPA, anticitrullinated peptide antibody; BMI, body mass index; RA, rheumatoid arthritis.