Table 4

OR with 95% CI of developing ACPA-positive and ACPA-negative RA for overweight and obese men compared with normal weight men stratified by smoking habits

ACPA-positive RAACPA-negative RA
BMICa/Co*Ca/Co*Ca/Co*OR (95% CI)†
Never smokers
Normal weight63/1161.0 (reference)48/1161.0 (reference)
Overweight56/1330.9 (0.6–1.3)59/1331.1 (0.7–1.7)
Obesity16/350.9 (0.5–1.6)14/350.8 (0.4–1.6)
P for trend0.970.8
Normal weight208/1621.0 (reference)78/1621.0 (reference)
Overweight210/2350.7 (0.6–0.9)104/2351.0 (0.7–1.3)
Obesity51/770.5 (0.4–0.8)39/771.2 (0.8–1.8)
P for trend0.0030.98
  • *Number of exposed cases and controls.

  • †Adjusted for age, gender, residential area, ancestry and study.

  • ACPA, anticitrullinated peptide antibody; BMI, body mass index; RA, rheumatoid arthritis.