OR with 95% CI of developing ACPA-positive and ACPA-negative RA for overweight and obese men compared with normal weight men stratified by smoking habits
| ACPA-positive RA | ACPA-negative RA | |||
| BMI | Ca/Co* | Ca/Co* | Ca/Co* | OR (95% CI)† |
| Never smokers | ||||
| Normal weight | 63/116 | 1.0 (reference) | 48/116 | 1.0 (reference) |
| Overweight | 56/133 | 0.9 (0.6–1.3) | 59/133 | 1.1 (0.7–1.7) |
| Obesity | 16/35 | 0.9 (0.5–1.6) | 14/35 | 0.8 (0.4–1.6) |
| P for trend | 0.97 | 0.8 | ||
| Ever-smokers | ||||
| Normal weight | 208/162 | 1.0 (reference) | 78/162 | 1.0 (reference) |
| Overweight | 210/235 | 0.7 (0.6–0.9) | 104/235 | 1.0 (0.7–1.3) |
| Obesity | 51/77 | 0.5 (0.4–0.8) | 39/77 | 1.2 (0.8–1.8) |
| P for trend | 0.003 | 0.98 | ||
*Number of exposed cases and controls.
†Adjusted for age, gender, residential area, ancestry and study.
ACPA, anticitrullinated peptide antibody; BMI, body mass index; RA, rheumatoid arthritis.