Table 2

The CCR, too low and too high classification rate of JADAS10 and cJADAS10 cut-off values for selected disease activity levels of JIA, CID according to Wallace,7 LDA and MDA as proposed by Beukelman et al10 and HDA as proposed by Backström et al13 using three different receiver operating characteristic curve-based methods: the one closest to point (0.1), the Youden index21 and the 75th centile

Cut-off rangeCCR (%)Too low (%)Too high (%)
Oligoarticular disease
CID7 (n=86)
 Closest to point≤0.5≤0.574.474.425.625.6
 Youden index≤0.3≤0.368.668.631.431.4
 75th centile≤0.6≤0.676.776.723.323.3
LDA10 (n=43)
 Closest to point0.6–3.60.6–3.662.862.827.927.99.39.3
 Youden index0.4–3.80.4–3.883.783.711.611.64.74.7
 75th centile0.7–2.80.7–2.848.848.827.927.923.323.3
MDA10 (n=46)
 Closest to point3.7–7.83.7–7.867.465.219.621.713.013.1
 Youden index3.9–7.83.9–7.859.
 75th centile2.9–6.72.9–6.765.263.010.913.023.924.0
HDA13 (n=8)
 Closest to point≥7.9≥7.962.562.537.537.5
 Youden index≥7.9≥7.962.562.537.537.5
 75th centile≥6.8≥6.875.
Average CCR of all disease activity levels (n=154)
 Closest to point66.866.3
 Youden index68.468.4
 75th centile66.465.9
Polyarticular disease
CID7 (n=72)
 Closest to point≤1.2≤1.276.476.423.623.6
 Youden index≤0.7≤0.765.365.334.734.7
 75th centile≤1.0≤1.076.476.423.623.6
LDA10 (n=33)
 Closest to point1.3–5.01.3–4.869.766.724.
 Youden index0.8–5.10.8–5.081.881.812.
 75th centile1.0–3.81.0–3.854.554.521.221.224.324.3
MDA10 (n=43)
 Closest to point5.1–16.04.9–
 Youden index5.2–16.05.1–16.069.769.825.627.94.72.3
 75th centile3.9–11.03.9–11.055.855.820.920.923.323.3
HDA13 n=6
 Closest to point≥16.0≥16.083.383.316.716.7
 Youden index≥16.0≥16.083.383.316.716.7
 75th centile≥11.0≥11.0100.0100.00.00.0
Average CCR of all disease activity levels (n=154)
 Closest to point75.475.2
 Youden index75.075.1
 75th centile71.771.7
  • CCR, correct classification rate; CID, clinically inactive disease; HDA, high disease activity; JADAS, Juvenile Arthritis Disease Activity Score; JIA, juvenile idiopathic arthritis; LDA, low disease activity; MDA, moderate disease activity; cJADAS, clinical JADAS.