Table 2

Characteristics of 20 patients from three centres

Patient	Age/ Sex	Tumour type	Checkpoint inhibitor	Fulfilled EULAR/ACR classification criteria*	Unfulfilled criteria	Atypical features	Treatment
Cleveland Clinic Foundation, Cleveland, Ohio, USA
1	63 M	RCC	Nivolumab	No; five points	Acute phase reactants		Prednisone 40 mg; tocilizumab 162 mg q2 weeks
2	69 M	Melanoma	Ipilimumab/ nivolumab	Yes; six points		Sicca symptoms; antinuclear antibody 1:1280, anti-Sjogren’s-syndrome-related antigen A >8 IU	Prednisone 30 mg
3	79 M	Melanoma	Ipilimumab/ nivolumab	Yes; seven points†		Sicca symptoms	Prednisone 20 mg
4	57 M	Melanoma	Pembrolizumab	No; three points	Acute phase reactants; RF 35 IU/mL; knee involvement		Prednisone 60 mg
5	60 M	Melanoma	Pembrolizumab	No; three points	RF 45 IU/mL; knee involvement		Prednisone 60 mg
6	66 M	Melanoma	Nivolumab	Yes; five points	Hand involvement		Prednisone 20 mg; methotrexate
7	69 F	RCC	Nivolumab	Yes; five points	Hand involvement		Prednisone 10 mg; tocilizumab 162 mg q2 weeks
8	66 M	RCC	Durvalumab; tremilimumab	Yes; five points	Hand involvement		Prednisone 20 mg
9	72 F	RCC	Avelumab	Yes; four points	Acute phase reactants; hand and knee involvement		Prednisone 20 mg
Johns Hopkins University, Baltimore, Maryland, USA
10	66 M	Lung adenocarcinoma	Pembrolizumab	No; six points	Shoulder aching		Prednisone 20 mg
11	63 F	Poorly differentiated carcinoma with squamous features	Durvalumab	Yes; six points			Prednisone 15 mg; hydroxychloroquine
12	59 F	Melanoma	Nivolumab	Yes; six points			Prednisone 7.5 mg; bilateral trochanter injections
13	76 M	Merkle cell carcinoma	Nivolumab	No; four points
Centre Hospitalier Universitaire, Bordeaux, France
14	81 M	Melanoma	Pembrolizumab	No; five points	Acute phase reactants; knee involvement		Prednisone 10 mg
15	74 M	Melanoma	Pembrolizumab	Yes; seven points†			Prednisone 15 mg
16	59 M	Melanoma	Pembrolizumab	No; seven points†*	Acute phase reactants		Prednisone 10 mg
17	65 F	NSCLC	Nivolumab	No; seven points†	Acute phase reactants		Prednisone 15 mg
18	63 M	NSCLC	Nivolumab	Yes; six points		Resolved with NSAIDs alone	NSAIDs
19	74 M	RCC	Ipilimumab/ nivolumab	Yes; five points	Hand involvement		Prednisone 10 mg
20	77 F	Melanoma	Pembrolizumab	Yes; six points†	Hip pain		Prednisone 15 mg

All patients had complete reporting to allow application of the EULAR/ACR classification criteria.
*A score of four or more is needed for PMR classification without ultrasound, and a score of five or more if ultrasound is included.
†Met ultrasound criteria.
ACR, American College of Rheumatology; EULAR, European League Against Rheumatism; NSAIDs, non-steroidal anti-inflammatory drugs; NSCLC, non-small cell lung cancer;PMR, polymyalgia rheumatica; RCC, renal cell carcinoma.