Table 5

Pathotype, disease activity and radiocarpal wrist joint imagining and biopsy data

Pathotype	All patients with RA								Control group
	Baseline biopsy (n=40)				6-month biopsy (n=40)				Baseline (n=16)
	Lymphoid	Myeloid	Fibroid	P value	Lymphoid	Myeloid	Fibroid	P value	Lymphoid	Myeloid	Fibroid	P value
n (%)	23 (57.5)	12 (30.0)	5 (12.5)		16 (40.0)	22 (55.0)	2 (5.0)		1 (6.3)	6 (37.5)	9 (56.3)
C-reactive protein, mean (SD)	20.9 (22.3)	17.5 (14.0)	6.4 (7.0)	0.02	11.6 (18.5)	8.3 (11.4)	2.3 (0.4)	0.01	1.0 (.)	2.8 (3.5)	1.1 (0.6)	0.39
DAS28CRP, mean (SD)	4.9 (0.9)	4.6 (1.0)	4.5 (1.2)	0.63	2.9 (1.1)	2.5 (1.1)	1.6 (0.0)	<0.01
ACPA and/or RF positive, n (%)	17 (74)	7 (58)	4 (80)	0.57	12 (75)	16 (73)	0 (0)	<0.01	0 (0)	0 (0)	0 (0)
Wrist Imaging Scores
X-ray Larsen, mean (SD)	2.8 (4.6)	1.5 (4.3)	0.0 (0.0)	0.02	4.8 (6.3)	0.4 (0.7)	1.0 (1.4)	0.04	0.0 (0.0)	0.0 (0.0)	0.0 (0.0)
US EULAR-OMERACT score
Combined score, mean (SD)	2.5 (0.7)	1.9 (0.7)	1.2 (0.4)	<0.01	2.0 (0.7)	1.6 (0.7)	2.0 (0.0)	0.08
Grey scale, mean (SD)	2.4 (0.7)	1.8 (0.6)	1.0 (0.0)	<0.01	1.9 (0.7)	1.6 (0.7)	2.0 (0.0)	0.08
Colour Doppler, mean (SD)	2.3 (0.8)	1.4 (0.9)	1.0 (0.7)	<0.01	1.7 (1.0)	0.9 (0.8)	1.0 (1.4)	0.07
RAMRIS score in wrist radiocarpal joint*
Synovitis (0–3), mean (SD)	2.1 (1.0)	1.1 (1.0)	0.2 (0.4)	<0.01	1.2 (0.4)	0.7 (0.5)		0.03	1.0 (.)	0.0 (0.0)	0.3 (0.5)	<0.01
Bone erosion (0–10), mean (SD)	0.9 (1.2)	0.5 (1.0)	0.2 (0.4)	0.12	0.2 (0.4)	0.1 (0.3)		0.75	0.0 (.)	0.0 (0.0)	0.0 (0.0)
Bone oedema (0–3), mean (SD)	0.3 (0.7)	0.0 (0.0)	0.0 (0.0)	0.03	0.0 (0.0)	0.1 (0.3)		0.34	0.0 (.)	0.0 (0.0)	0.0 (0.0)
Synovial tissue inflammation
Krenn score, mean (SD)	7.1 (1.6)	5.9 (1.5)	4.2 (0.4)	<0.01	6.2 (1.7)	5.0 (1.4)	6.0 (0.0)	<0.01	7.0 (.)	4.8 (0.7)	3.4 (1.7)	<0.01
Specific markers (0–4)
CD20, mean (SD)	2.3 (1.2)	0.7 (0.5)	0.0 (0.0)	<0.01	2.1 (1.1)	0.5 (0.5)	0.0 (0.0)	<0.01	1.0 (.)	0.5 (0.5)	0.0 (0.0)	0.05
CD3, mean (SD)	2.8 (1.0)	1.7 (0.6)	0.4 (0.5)	<0.01	2.5 (1.0)	1.8 (0.7)	1.0 (0.0)	<0.01	2.0 (.)	1.0 (0.6)	0.4 (0.5)	<0.01
CD68, mean (SD)	3.3 (0.8)	2.5 (0.5)	2.0 (0.0)	<0.01	3.0 (0.8)	2.4 (0.7)	2.0 (1.4)	0.08	3.0 (.)	2.0 (0.6)	1.1 (0.6)	<0.01
CD138, mean (SD)	2.5 (1.1)	0.6 (0.5)	0.0 (0.0)	<0.01	2.6 (0.6)	0.9 (0.6)	0.0 (0.0)	<0.01	2.0 (.)	0.3 (0.5)	0.1 (0.3)	<0.01

*LRA not MRI at 6 months, one patient with ERA did not undergo MRI due to claustrophobia, six control MRI without use of contrast agent. Seven controls without wrist X-ray before biopsy. Significant p values in bold. Comparison by unadjusted linear regression with cluster robust standard errors.
ACPA, anti-citrullinated proteins antibody; DAS28CRP, disease activity score in 28 joints with CRP level included; ERA, early RA; LRA, long-standing RA; RA, rheumatoid arthrits; RF, rheumatoid factor.