Table 2

Biomarkers’ change from baseline to week 24 between the second TNFi and other biological groups

Second TNFi (n=96)Other biologic (n=107)P value second TNFi versus other biologic*
ApoA1 (g/L)Median baseline (IQR)1.74 (1.54 to 2.03)1.7 (1.5 to 1.93)
Median change (IQR)0.03 (−0.12 to 0.16)0.005 (−0.13 to 0.24)0.46
P-value of change W24 versus baseline†<0.001<0.001
Median % of change (IQR)1.23 (−6.13 to 9.84)0 (−6.92 to 14.37)
ApoB100 (g/L)Median baseline (IQR)1.01 (0.87 to 1.16)1.04 (0.86 to 1.20)
Median change (IQR)−0.01 (−0.09 to 0.08)0.04 (−0.07 to 0.12)0.037
P-value of change W24 versus baseline‡0.5360.072
Median % of change (IQR)−1.2 (−9.35 to 7.45)3.49 (−5.26 to 11.83)
ApoB100/ApoA1 ratioMedian baseline (IQR)0.54 (0.46 to 0.69)0.63 (0.47 to 0.72)0.076
Median change (IQR)−0.01 (-0.08 to 0.05)0.01 (−0.07 to 0.08)
P-value of change W24 versus baseline‡0.1560.734
Median % of change (IQR)−2.09 (−12.97 to 9.76)1.52 (−11.63 to 12.82)
Lp(a) (g/L)Median baseline (IQR)0.10 (0.05 to 0.29)0.15 (0.06 to 0.33)
Median change (IQR)−0.005 (−0.02 to 0.01)−0.01 (−0.05 to 0.01)0.051
P-value of change W24 versus baseline‡0.0580.017
Median % of change (IQR)−1.72 (−22.74 to 8.62)−1.28 (−30 to 14.29)
Leptin (ng/mL)Median baseline (IQR)9.90 (5.22 to 22)11.74 (5.70 to 28.4)
Median change (IQR)0.47 (−2.1 to 2.56)−0.78 (−4.1 to 2.38)0.13
P-value of change W24 versus baseline‡0.4190.068
Median % of change (IQR)5.62 (−22.72 to 33.95)−8.85 (−30.18 to 18.22)
Adiponectin (mg/L)Median baseline (IQR)7.25 (5 to 9.93)7.92 (5.64 to 11.2)
Median change (IQR)0.1 (−0.63 to 0.79)0.17 (−0.89 to 0.95)0.79
P-value of change W24 versus baseline‡0.5050.471
Median % of change (IQR)1.35 (−7.85 to 11.61)2.57 (−11.69 to 12.36)
Leptin/adiponectin ratio (ng/µg)Median baseline (IQR)1.55 (0.62 to 2.82)1.47 (0.77 to 3.51)
Median change (IQR)0.04 (−0.19 to 0.43)−0.12 (−0.58 to 0.31)0.033
P-value of change W24 versus baseline‡0.2170.052
Median % of change (IQR)3.64 (−17.91 to 36.14)−9.74 (−30.23 to 27.67)
  • Statistical analysis.

  • *ANCOVA model.

  • †Paired Student’s t-test.

  • ‡Wilcoxon signed rank test.

  • ANCOVA, analysis of covariance; Apo, apolipoprotein; Lp(a), lipoprotein(a); TNFi, tumour necrosis factor inhibitor; W24, week 24.