Table 1

Descriptive data of 1011 patients with early RA at baseline and after 24 months of disease

VariablesBaseline24 months
Age, median (IQR), years59.0 (18)
Symptom duration until inclusion and diagnose, median (IQR), months6 (5)
Smoker ever, n (%)637 (64.7)
Current smoker, n (%)205 (20.3)
RF+, n (%)735 (74.2)
Anti-CCP2+, n (%)680 (67.5)
HLA-SE, n/n total, (%)624/1001 (62.3)
PTPN22 T-carrier, n (%)637 (64.7)
BMI, median (IQR)25.8 (5.4)
DAS28, median (IQR)4.7 (1.9)3.0 (1.9)
DAS28-AUC*, median (IQR)82.7 (28.1)
TJC, median (IQR)5 (8)1.0 (4.0)
TJC AUC*, median (IQR)63.0 (64.1)
SJC, median (IQR)6 (7)1.0 (4.0)
SJC AUC*, median (IQR)69.0 (58.1)
HAQ, median (IQR)0.9 (0.9)0.5 (0.75)
HAQ AUC*, median (IQR)14.0 (10.0)
CRP, median (IQR), mg/L10 (21)5.0 (7.0)
CRP AUC*, median (IQR)222.0 (206.0)
ESR, median (IQR), mm/h22 (28)12.0 (15.0)
ESR AUC*, median (IQR)406.5 (262.5)
Pain, median (IQR), mm45 (42)24.0 (38.0)
Pain AUC*, median (IQR)738.0 (355.1)
PGA, median (IQR), mm47 (40)27.0 (39.0)
PGA AUC*, median (IQR)810.0 (373.2)
Larsen score, median (IQR)5 (8)9.0 (8.8)
cDMARDs†, n (%)879 (89.4)952 (96.2)
cDMARDs, median (IQR), months24.0 (5.0)
Corticosteroids‡, n (%)494 (50.6)159 (22.9)
Corticosteroids, median (IQR), months8.0 (22.0)
bDMARDs§, n (%)0 (0)93 (9.4)
bDMARDs, median (IQR), months12 (10)¶
  • *AUC calculated for 24 months.

  • †Conventional DMARDs prescribed at baseline: methotrexate, sulfasalazine, chloroquine, azathioprine and ciclosporin and also during the 24 months: myocrisine and leflunomide.

  • ‡Corticosteroids ≤7.5 mg daily of prednisolone prescribed at baseline or during the 24 months.

  • §Biological DMARDs: adalimumab, etanercept and infliximab after baseline.

  • ¶Median time for start of therapy after onset 12 months.

  • anti-CCP2, anticyclic citrullinated peptide-2; AUC, area under curve; BMI, body mass index; CRP, C reactive protein; DAS, Disease Activity Score; DMARDs, disease-modifying antirheumatic drugs; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; PGA, Patients Global Assessment; RA, rheumatoid arthritis ; SJC, swollen joint count;TJC, tender joint count.