Table 4

Kappa’s agreement between MDA and alternate disease activity criteria

Author (year)Study descriptionSample sizeTime pointCriterionκ
Measures of disease activity
Coates and Helliwell (2016)32Prospective longitudinal observational study of GRACE dataset collected from 32 countries to explore the relationship between MDA and low disease activity cutoffs503Week 24PASDAS0.73
CPDAI-40.75
CPDAI-30.75
Rahman et al (2017)33Prospective longitudinal observational study22312 monthsDAS28 (<2.6)0.65
DAS28 deep remission (1.98)0.60
DAPSA remission (≤4)0.65
Lubrano et al (2015)34Prospective longitudinal observational study to compare PtGA with MDA and other outcome measures.1244 monthsPtGA0.73
8 monthsPtGA0.72
12 monthsPtGA0.73
Categorical measures
Coates and Helliwell (2016)32Described above503Week 24MDA-joints*0.86
MDA-phys†0.48
  • *BSA, and not the PASI, was the cut-off used for the skin domain.

  • †MDA as judged by the treating physician=do you think this patient is in an MDA state? (yes/no).

  • BSA, body surface area; CPDAI, Composite Psoriatic Disease Activity Index; DAPSA, Disease Activity in Psoriatic Arthritis; DAS28, Disease Activity Score using 28 joints; GRACE, Group for Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Composite Disease Exercise; MDA, minimal disease activity; PASDAS, Psoriatic Arthritis Disease Activity Score; PASI, Psoriasis Area and Severity Index; PtGA, patient global assessment.