Table 1

Relationship between MDA status and CRP

Author (year)Study descriptionSample sizeMDA subgroupCRP score,
median (IQR); mean (SD)
Coates and Helliwell (2010)22Post hoc analysis of two RCTs to validate the MDA criteria157MDA (n=63)Median, 0.4 mg/dL (0.4–0.6)
Non-MDA (n=94)Median, 0.5 mg/dL (0.4–1.3)
P value0.019
Queiro et al (2017)25Cross-sectional observational study277MDA (n=133)Mean, 2.8 mg/L (3.9)
Non-MDA (n=144)Mean, 4.7 mg/L (8.2)
P value<0.05
  • CRP, C reactive protein; MDA, minimal disease activity; Non-MDA, patients not achieving MDA; RCT, randomised controlled trial.