Table 3

Relationship between MDA status and PRO measures

Author (year)	Study description	Sample size	Time point	Criterion variable	MDA subgroup	Score
Cross-sectional studies						Mean (SD)
Queiro et al (2017)25	Cross-sectional observational study	277	—	PsAID total score*	MDA	3.3 (3.1)
					Non-MDA	7.1 (5.2)
					P value	<0.001
Longitudinal studies						Change from baseline
Mease et al (2017a)31	Post hoc analysis of RCT to validate MDA criteria and HRQoL outcomes	135	Week 24	SF-36 PCS	MDA	13.3
					Non-MDA	3.5
					P value	<0.001
				SF-36 MCS	MDA	5.0
					Non-MDA	0.3
					P value	<0.01
				DLQI total	MDA	−5.8
					Non-MDA	−2.8
					P value	0.01
				FACIT Fatigue	MDA	8.6
					Non-MDA	1.3
					P value	0.001
Coates et al (2016)30	Post hoc analysis of RCT to validate MDA criteria and HRQoL outcomes	397	Week 24	SF-36 PCS	MDA	9.0
					Non-MDA	4.6
					P value	<0.001
				SF-36 MCS	MDA	6.9
					Non-MDA	4.1
					P value	<0.01
				DLQI	MDA	−9.9
					Non-MDA	−7.5
					P value	<0.01
				FACIT fatigue	MDA	9.0
					Non-MDA	4.9
					P value	<0.001
				PsA QoL	MDA	−5.2
					Non-MDA	−3.3
					P value	<0.001
			Week 52	SF-36 PCS	MDA	9.9
					Non-MDA	4.6
					P value	<0.001
				SF-36 MCS	MDA	6.8
					Non-MDA	4.4
					P value	<0.01
				DLQI	MDA	−10.7
					Non-MDA	−8.5
					P value	<0.01
				FACIT fatigue	MDA	9.5
					Non-MDA	5.4
					P value	<0.001
				PsA QoL	MDA	−5.7
					Non-MDA	−3.4
					P value	<0.001

*PsAID total score ranges from 0 (best health status) to 10 (worst health status).
DLQI, Dermatology Life Quality Index; FACIT, Functional Assessment of Chronic Illness Therapy; HRQoL, health-related quality of life;MCS, Mental Component Score; MDA, minimal disease activity; Non-MDA, patients not achieving MDA;PCS, Physical Component Score; PROs, patient-reported outcomes; PsAID, Psoriatic Arthritis Impact of Disease; PsA QoL, psoriatic arthritis quality of life; RCT, randomised controlled trial; SF-36, Short Form 36 Health Survey.