Table 2

Laboratory markers of disease activity in TAK

TAK (N)Circulating laboratorial markersStudied groupsResultsP valueNOS score
Goel et al 24 32ESRActive vs stable36.5 (range 14.0–70.8) vs
20.0 (range 13.5–43.0)
CRPActive vs stable4.5 (range 1.1–33.2) vs
3.4 (range 0.6–11.0)
IL-6Active vs stable18.2 (range 3.2–46.2) vs
9.6 (range 4.8–16.33)
de Souza and Ataide Mariz25 59ESRActive vs inactive54.8±30.9 vs 18.1±15.00.0154
ET-1Active vs inactive1.70±0.46 vs 1.43±0.44NS
Park et al 23 47ESRActive vs stable41.1±18.8 vs 14.4±9.60.013
CRPActive vs stable1.2±1.1 vs 0.6±0.4NS
Park et al 31 49ESRActive vs stable44.4±19.0 vs 12.5±8.8<0.053
IL-6Active vs stable54.3±21.2 vs 14.7±5.5<0.05
IL-18Active vs stable850.0±211.1 vs 378.7±154.1<0.001
  • This scale assesses the quality of studies based on a ‘star/points system’ and evaluates studies according to three main considerations: selection of study groups; comparability of the groups; and ascertainment of either the exposure or outcome of interest for case–control or cohort studies, respectively. The maximum score is 9. The RoB decreases inversely to the score.

  • CRP, C reactive protein in mg/L; ESR, erythrocyte sedimentation rate in millimetre/first hour; ET-1, endothelin-1 in pg/mL; IL-6, interleukin-6 in pg/mL;IL-18, interleukin-18 in pg/mL; NOS, Newcastle-Ottawa Scale; NS, non-significant; TAK, Takayasu arteritis.