Table 3

Sensitivity analysis in complete cases (n=8182); pathways between osteoarthritis and mortality via walking frequency, depression, anxiety and unrefreshed sleep: total, direct and indirect effects

MediatorAssociation between osteoarthritis and potential mediatorPathwayAdjusted HR (95% CI)
Total effect (no mediators)1.14(1.00to1.29)
Walking frequencyDirect1.07 (0.96 to 1.26)
 Frequent walkerReferenceIndirect1.06(1.04to1.08)
 Non-frequent walker2.03(1.82 to2.26)Total1.13(1.02to1.33)
DepressionDirect1.09 (0.98 to 1.23)
 No depressionReferenceIndirect1.04(1.02to1.06)
 Depression2.42(2.11 to2.77)Total1.13(1.01to1.27)
AnxietyDirect1.13 (0.99 to 1.25)
 No anxietyReferenceIndirect1.00 (0.98 to 1.02)
 Anxiety2.01(1.80 to2.26)Total1.13(1.00to1.26)
 Not unrefreshedReferenceIndirect1.01(1.00to1.03)
 Unrefreshed2.15(1.88 to2.47)Total1.14(1.01to1.29)
  • All models adjusted for age, sex, education, occupation, smoking status, cognitive behaviour, BMI, consultation for ischaemic heart disease, chronic obstructive pulmonary disease, diabetes, non-steroidal anti-inflammatories and self-report of heart conditions.

  • Significant associations between predictor and mediator and indirect effects are in bold.

  • BMI, body mass index.