Sensitivity analysis in complete cases (n=8182); pathways between osteoarthritis and mortality via walking frequency, depression, anxiety and unrefreshed sleep: total, direct and indirect effects
| Mediator | Association between osteoarthritis and potential mediator | Pathway | Adjusted HR (95% CI) |
| – | Total effect (no mediators) | 1.14(1.00to1.29) | |
| Walking frequency | Direct | 1.07 (0.96 to 1.26) | |
| Frequent walker | Reference | Indirect | 1.06(1.04to1.08) |
| Non-frequent walker | 2.03(1.82 to2.26) | Total | 1.13(1.02to1.33) |
| Depression | Direct | 1.09 (0.98 to 1.23) | |
| No depression | Reference | Indirect | 1.04(1.02to1.06) |
| Depression | 2.42(2.11 to2.77) | Total | 1.13(1.01to1.27) |
| Anxiety | Direct | 1.13 (0.99 to 1.25) | |
| No anxiety | Reference | Indirect | 1.00 (0.98 to 1.02) |
| Anxiety | 2.01(1.80 to2.26) | Total | 1.13(1.00to1.26) |
| Unrefreshed | Direct | 1.13(1.01to1.28) | |
| Not unrefreshed | Reference | Indirect | 1.01(1.00to1.03) |
| Unrefreshed | 2.15(1.88 to2.47) | Total | 1.14(1.01to1.29) |
All models adjusted for age, sex, education, occupation, smoking status, cognitive behaviour, BMI, consultation for ischaemic heart disease, chronic obstructive pulmonary disease, diabetes, non-steroidal anti-inflammatories and self-report of heart conditions.
Significant associations between predictor and mediator and indirect effects are in bold.
BMI, body mass index.