Summary of studies included for data extraction
| Risk of bias | Outcomes* | |||||||
| Type of study | Number n=60 | Low n=40 | Unclear n=20 | High n=0 | Clinical presentation n=54 | Burden disease n=44 | Treatment n=19 | Treatment effect† n=9 |
| RCTs | 10 (16.7%) | 7 | 3 | 0 | 6 | 4 | 1 | 9 |
| Cohort | 12 (20.0%) | 9 | 3 | 0 | 12 | 10 | 8 | 0 |
| Cross-sectional | 36 (60.0%) | 23 | 13 | 0 | 34 | 29 | 10 | 0 |
| Case–control | 2 (3.3%) | 1 | 1 | 0 | 2 | 1 | 0 | 0 |
*One study can address more than one outcome.
†manuscripts reporting the results of three randomised clinical trials.
RCTs, randomised controlled trials.