Impact of positive status for 14-3-3η ≥0.50 ng/mL (High-14-3-3η), positive rheumatoid factor (RF) and positive anti-CCP2 (ACPA) on prediction of rapid erosive progression (REP; ≥5 erosion units between two successive visits) according to normal (≤8.0 mg/L) or high C-reactive protein (High-CRP) at a given visit
| Visits | REP (ΔErosions ≥5 between 2 visits) | |||
|---|---|---|---|---|
| Total | n (%) | RR (95% CI) | P value | |
| Normal CRP (≤8.0 mg/L) | ||||
| Individual variables | ||||
| High 14-3-3η | 453 | 30 (6.6) | 1.15 (0.72–1.85) | 0.5627 |
| ACPA positive | 468 | 40 (8.5) | 2.51 (1.59–3.98) | <0.0001 |
| RF positive | 481 | 46 (9.6) | 2.75 (1.70–4.47) | <0.0001 |
| RF, ACPA | (n=1284) | |||
| Both negative | 713 | 19 (2.7) | 1 | |
| One positive | 251 | 20 (8) | 2.97 (1.65–5.35) | 0.0003 |
| Both positive | 320 | 29 (9.1) | 3.48 (1.99–6.10) | <0.0001 |
| 14-3-3η, RF | (n=1383) | |||
| Both negative | 721 | 31 (4.3) | 1 | |
| One positive | 403 | 18 (4.5) | 1.15 (0.63–2.09) | 0.6497 |
| Both positive | 259 | 29 (11.2) | 2.37 (1.35–4.17) | 0.0026 |
| 14-3-3η, ACPA | (n=1238) | |||
| Both negative | 593 | 21 (3.5) | 1 | |
| One positive | 435 | 30 (6.9) | 1.86 (1.14–3.05) | 0.0138 |
| Both positive | 210 | 17 (8.1) | 2.21 (1.18–4.15) | 0.0130 |
| 14-3-3η, RF, ACPA | (n=1233) | |||
| All negative | 537 | 18 (3.4) | 1 | |
| One positive | 298 | 15 (5) | 1.52 (0.81–2.84) | 0.1922 |
| Two positive | 226 | 18 (8) | 2.38 (1.26–4.50) | 0.0076 |
| All positive | 172 | 17 (9.9) | 2.93 (1.54–5.57) | 0.0011 |
| High CRP (˃8.0 mg/L) | ||||
| Individual variables | ||||
| High 14-3-3η | 241 | 59 (24.5) | 2.23 (1.54–3.22) | <0.0001 |
| ACPA positive | 259 | 63 (24.3) | 2.52 (1.60–3.97) | <0.0001 |
| RF positive | 281 | 69 (24.6) | 2.43 (1.57–3.75) | <0.0001 |
| RF, ACPA | (n=654) | |||
| Both negative | 346 | 26 (7.5) | 1 | |
| One positive | 102 | 15 (14.7) | 1.85 (0.95–3.59) | 0.0703 |
| Both positive | 206 | 56 (27.2) | 3.22 (1.96–5.27) | <0.0001 |
| 14-3-3η, RF | (n=700) | |||
| Both negative | 349 | 30 (8.6) | 1 | |
| One positive | 190 | 26 (13.7) | 1.8 (1.12–2.9) | 0.0154 |
| Both positive | 161 | 51 (31.7) | 3.52 (2.2–5.64) | <0.0001 |
| 14-3-3η, ACPA | (n=642) | |||
| Both negative | 310 | 23 (7.4) | 1 | |
| One positive | 191 | 29 (15.2) | 2.18 (1.31–3.65) | 0.0029 |
| Both positive | 141 | 44 (31.2) | 3.93 (2.30–6.73) | <0.0001 |
| 14-3-3η, RF, ACPA | (n=641) | |||
| All negative | 285 | 22 (7.7) | 1 | |
| One positive | 113 | 7 (6.2) | 1.14 (0.58–2.24) | 0.7084 |
| Two positive | 121 | 27 (22.3) | 3.18 (1.71–5.90) | 0.0003 |
| All positive | 122 | 40 (32.8) | 4.31 (2.46–7.56) | <0.0001 |