Patients with RA | Full siblings of the patients with RA | Matched reference individuals in the general population | Full siblings of the matched reference individuals in the general population | |
---|---|---|---|---|
N | 8137 | 10 261 | 22 457 | 28 878 |
Median age (IQR) | 55.3 (14.6) | 55.3 (14.4) | 54.4 (14.8) | 54.5 (14.7) |
Women (%) | 5596 (68.8) | 5005 (48.8) | 15 371 (68.4) | 14 335 (49.6) |
Median years of follow-up (IQR) | 6.9 (7.0) | 7.0 (7.3) | 6.9 (7.1) | 7.1 (7.2) |
Events (%) | 608 | 756 | 1 397 | 1 833 |
Age- and sex-standardised mortality rate (95% CI) | 9.9 (9.1 to 10.7) | 9.0 (8.4 to 9.7) | 8.9 (8.4 to 9.3) | 8.1 (7.7 to 8.5) |
HR (95% CI) | 1.11 (1.01 to 1.22)* | 1.10 (1.01 to 1.20)† | ||
Rheumatoid factor-positive RA | ||||
N | 5269 | 6695 | 14 557 | 18 900 |
Median age (IQR) | 54.9 (14.2) | 54.9 (14.1) | 54.1 (14.5) | 54.3 (14.4) |
Women (%) | 3734 (70.9) | 3271 (48.9) | 10 217 (70.2) | 9447 (50.0) |
Median years of follow-up (IQR) | 7.2 (7.2) | 7.5 (7.6) | 7.3 (7.4) | 7.5 (7.5) |
Events | 431 | 484 | 894 | 1 235 |
Age- and sex-standardised mortality rate (95% CI) | 11.1 (10.0 to 12.2) | 8.9 (8.1 to 9.7) | 8.7 (8.1 to 9.3) | 8.1 (7.7 to 8.6) |
HR (95% CI) | 1.25 (1.12 to 1.40)* | 1.07 (0.96 to 1.19)† | ||
Rheumatoid factor-negative RA | ||||
N | 2868 | 3566 | 7900 | 9978 |
Median age (IQR) | 56.1 (15.1) | 56.1 (14.8) | 54.9 (15.4) | 54.7 (15.3) |
Women (%) | 1862 (64.9) | 1734 (48.6) | 5154 (65.2) | 4888 (49.0) |
Median years of follow-up (IQR) | 6.3 (6.5) | 6.3 (6.8) | 6.2 (6.5) | 6.4 (6.7) |
Events | 177 | 272 | 503 | 598 |
Age- and sex-standardised mortality rate (95% CI) | 7.7 (6.5 to 8.8) | 9.4 (8.3 to 10.6) | 9.1 (8.3 to 10.0) | 8.1 (7.4 to 8.7) |
HR (95% CI) | 0.86 (0.73 to 1.02)* | 1.16 (1.01 to 1.34)† |
*Adjusted for age, sex and time of inclusion, and compared with the general population comparator subjects.
†Adjusted for age, sex and time of inclusion, and compared with the siblings of the general population comparator subjects.
RA, rheumatoid arthritis.