Table 1

Demographics of the study population of Swedish patients with new-onset RA identified in the Swedish Rheumatology Quality Register, and followed from the RA diagnosis of the index patient (2001–2017) for all-cause mortality up until the end of 2018, overall and stratified by the index patient’s RA sero-status

Patients with RAFull siblings of the patients with RAMatched reference individuals in the general populationFull siblings of the matched reference individuals in the general population
N813710 26122 45728 878
Median age (IQR)55.3 (14.6)55.3 (14.4)54.4 (14.8)54.5 (14.7)
Women (%)5596 (68.8)5005 (48.8)15 371 (68.4)14 335 (49.6)
Median years of follow-up (IQR)6.9 (7.0)7.0 (7.3)6.9 (7.1)7.1 (7.2)
Events (%)6087561 3971 833
Age- and sex-standardised mortality rate (95% CI)9.9 (9.1 to 10.7)9.0 (8.4 to 9.7)8.9 (8.4 to 9.3)8.1 (7.7 to 8.5)
HR (95% CI)1.11 (1.01 to 1.22)*1.10 (1.01 to 1.20)†
Rheumatoid factor-positive RA
N5269669514 55718 900
Median age (IQR)54.9 (14.2)54.9 (14.1)54.1 (14.5)54.3 (14.4)
Women (%)3734 (70.9)3271 (48.9)10 217 (70.2)9447 (50.0)
Median years of follow-up (IQR)7.2 (7.2)7.5 (7.6)7.3 (7.4)7.5 (7.5)
Events4314848941 235
Age- and sex-standardised mortality rate (95% CI)11.1 (10.0 to 12.2)8.9 (8.1 to 9.7)8.7 (8.1 to 9.3)8.1 (7.7 to 8.6)
HR (95% CI)1.25 (1.12 to 1.40)*1.07 (0.96 to 1.19)†
Rheumatoid factor-negative RA
N2868356679009978
Median age (IQR)56.1 (15.1)56.1 (14.8)54.9 (15.4)54.7 (15.3)
Women (%)1862 (64.9)1734 (48.6)5154 (65.2)4888 (49.0)
Median years of follow-up (IQR)6.3 (6.5)6.3 (6.8)6.2 (6.5)6.4 (6.7)
Events177272503598
Age- and sex-standardised mortality rate (95% CI)7.7 (6.5 to 8.8)9.4 (8.3 to 10.6)9.1 (8.3 to 10.0)8.1 (7.4 to 8.7)
HR (95% CI)0.86 (0.73 to 1.02)*1.16 (1.01 to 1.34)†
  • *Adjusted for age, sex and time of inclusion, and compared with the general population comparator subjects.

  • †Adjusted for age, sex and time of inclusion, and compared with the siblings of the general population comparator subjects.

  • RA, rheumatoid arthritis.