Table 2

Urine and serum S100A8/A9 and S100A12 predict renal disease in SLE

Individual models
All patientsAnti-dsDNA negativeAnti-dsDNA positiveNormal serum complement C3 and/or C4Low serum complement C3 and/or C4
OR (CI)P valueAUCOR (CI)P valueAUCOR (CI)P valueAUCOR (CI)P valueAUCOR (CI)P valueAUC
Serum S100A8/A90.9
(0.62–1.3)
0.90.4680.9
(0.5–1.7)
0.80.4911 (0.6–1.7)0.80.4900.6
(0.3–1.2)
0.10.4361.3
(0.8–2)
0.30.55
Serum S100A120.7
(0.54–0.93)
0.015 0.3760.68
(0.5–0.9)
0.042 0.3470.8
(0.5–1.3)
0.40.4440.6
(0.4–0.9)
0.014 0.3190.9
(0.6–1.4)
0.70.482
Urine S100A8/A91.36
(1.1–1.68)
0.004 0.6231.2
(0.9–1.7)
0.20.5381.4
(1–1.9)
0.012 0.6871.3
(0.9–1.7)
0.080.5911.4
(1–2)
0.03 0.656
Urine S100A121.12
(0.98–1.26)
0.0780.5900.9
(0.9–0.7)
0.30.4331.3
(1–1.6)
0.011 0.6850.9
(0.8–1.2)
0.90.5221.2
(0.9–1.4)
0.070.63
Three-analyte model
Urine S100A8/A9
serum S100A12
Serum S100A8/A9
1.35 (1–1.7)
0.6 (0.4–1)
1.6 (0.8–3)
0.009
0.052
0.16
0.681------------
Four-analyte model
Urine S100A8/A9
Serum S100A12
Urine S100A12
Serum S100A8/A9
1.3 (1–1.7)
0.6 (0.3–0.99)
1.03 (0.9–1.2)
1.6 (0.8–3)
0.048
0.049
0.65
0.16
0.6781.4 (0.9–2)
0.6 (0.5–1)
0.8 (0.7–1)
1.6 (6–4)
0.09
0.09
0.2
0.3
0.7081.3 (0.9–2)
0.9 (0.4–2.6)
1.2 (0.9–1.5)
1.1 (0.4–0.5)
0.2
0.9
0.2
0.8
0.7021.6 (1–2.3)
0.6 (0.4–1)
0.8 (0.7–1.1)
0.9 (0.4–2.3)
0.029
0.07
0.2
0.9
0.7151.3 (0.8–1.9)
0.6 (0.2–1.8)
1 (0.9–1.4)
2.3 (0.7–7.5)
0.3
0.4
0.4
0.2
0.696
  • Significant differences were highlighted using bold letters.

  • Displayed are ORs and area under the curve (AUC) analyses for S100 proteins alone and in combination with outcome of renal disease. ORs, CIs and p values are displayed.

  • Anti-dsDNA, anti-double-stranded DNA.