Table 2

Pregnancy outcome and treatment in seronegative and seropositive APS

Seronegative APS pregnancies (n=108)

Seropositive APS pregnancies (n=75)

APS features
Thrombotic APS
 Arterial APS (n; %)020 (27)†
Venous APS (n; %)8 (7)42 (56)†
Obstetrical APS (n; %)93 (86)36 (48)†
Mix APS (n; %)6 (6)18 (24)†
Non-criteria features (n; %)18 (17)34 (45)†
Previous obstetrical history
 Miscarriages (n; %)49 (45)8 (11)†
 Intrauterine deaths (n; %)29 (27)16 (21)
 Prematurity <34 weeks of gestation (n; %)24 (22)14 (19)
Subsequent pregnancy treatments
Aspirin (n; %)/aspirin alone95 (88)/32 (30)57 (76)†/2 (3)†
LMWH isocoagulant amounts (n; %)63 (58)39 (52)
LMWH curative amounts (n; %)2 (2)33 (44)†
Aspirin-LMWH (n; %)65 (60)55 (73)
Prednisone (n; %)10 (9)4 (5)
Hydroxychloroquine (n; %)10 (9)8 (11)
Venous thrombosis (n; %)01 (1)
Pregnancy outcome
Preeclampsia/HELLP syndrome (n; %)7 (7)12 (16)†
Intrauterin growth restriction (IUGR) (n; %)5 (5)7 (10)
Oligoamnios (n; %)2 (2)1 (1)
Fetal loss (n; %)
miscarriage/intrauterine deaths
33 (31)
23 (21)/5 (5)
22 (29)
11 (15)/11 (15)†
Prematurity <34 weeks of gestation (n; %)6 (6)9 (12)
Term of fetal loss (weeks of gestation)10±813±7
Live births (n; %)75 (69)53 (70)
Term of live birth (weeks of gestation)38±336±3†
  • †p<0.05.

  • Values are numbers with frequencies and means with SD.

  • APS, antiphospholipid syndrome; HELLP, hemolysis, Elevated Liver enzymes and Low platelet count; LMWH, low-molecular weighted heparin.