Association between autoantibodies and HRCT parenchymal lung abnormalities
| Adjusted for age, sex and ever smoking | Adjusted for age, sex, ever smoking and any RF | |||
|---|---|---|---|---|
| OR (95% CI) | P value (adjusted p value) | OR (95% CI) | P value (adjusted p value) | |
| Any RF | 2.5 (1.0–6.2) | 0.05 (0.9) | ||
| RF (IgM) | 2.5 (1.0–6.2) | 0.05 (0.9) | ||
| RF (IgA) | 3.1 (1.3–7.6) | 0.01 (0.2) | ||
| Any anti-CCP2 | 5.2 (1.9–14.7) | 0.002 (0.04) | 5.6 (1.5–20.3) | 0.01 (0.2) |
| CCP2 (IgG) | 4.6 (1.7–12.4) | 0.003 (0.05) | 4.7 (1.3–17.3) | 0.02 (0.3) |
| CCP2 (IgA) | 1.5 (0.6–3.8) | 0.37 | 1.1 (0.4–3.1) | 0.79 |
| CEP-1 | 1.4 (0.6–3.2) | 0.48 | 1.0 (0.4–2.6) | 0.93 |
| CCP-1 | 2.1 (0.9–5.0) | 0.09 | 1.5 (0.6–3.9) | 0.4 |
| Any anti-cit vimentin | 3.1 (1.2–7.9) | 0.02 (0.4) | 2.3 (0.8–6.9) | 0.13 |
| Vim 2-17 | 2.2 (0.9–5.2) | 0.09 | 1.6 (0.6–4.1) | 0.37 |
| Vim 60-75 | 2.7 (1.1–6.6) | 0.03 (0.6) | 2.0 (0.7–5.4) | 0.17 |
| Any anit-cit fibrinogen | 4.9 (1.8–13.9) | 0.002 (0.04) | 4.2 (1.2–14.7) | 0.03 (0.5) |
| Fibα 36-50 | 1.6 (0.6–4.2) | 0.30 | 1.4 (0.5–3.6) | 0.54 |
| Fibα 563-583 | 2.8 (1.2–6.9) | 0.02 (0.4) | 2.1 (0.8–5.7) | 0.13 |
| Fibα 580600 | 1.2 (0.4–3.4) | 0.77 | 0.8 (0.2–2.4) | 0.65 |
| Fibα 621-635 | 1.9 (0.8–4.5) | 0.16 | 1.4 (0.5–3.6) | 0.51 |
| Fibβ 36-52 | 1.9 (0.8–4.4) | 0.13 | 1.4 (0.6–3.5) | 0.46 |
| Fibβ 60-74 | 2.4 (1.0–5.7) | 0.05 (0.9) | 1.6 (0.5–5.0) | 0.45 |
| Number of ACPA fine specificities | ||||
| 0 | Reference | Reference | ||
| 1–5 | 3.8 (1.2–12.1) | 0.03 | 3.1 (0.9–10.9) | 0.07 |
| >5 | 6.0 (1.8–20.1) | 0.004 | 4.5 (1.1–18.8) | 0.04 |
| 0–1 | Reference | Reference | ||
| >1 | 2.9 (1.1–7.4) | 0.03 | 2.0 (0.6–6.4) | 0.24 |
| No. of ACPA fine specificities (as continuous) | 1.2 (1.0–1.3) | 0.04 | 1.09 (1.0–1.3) | 0.23 |
The table represents the results from logistic regression analysis. The OR on the left column are adjusted for age, sex and smoking while the right column is adjusted for age, sex, ever smoking and any RF, with HRCT parenchymal lung abnormalities as the outcome variable and several types of autoantibodies and ACPA specificities as independent variables. The bolded values represent a statistically significant OR (p<0.05). The p values in parentheses represent the adjusted values for multiple test (Bonferroni).
ACPA, anticitrullinated protein/peptide antibodies; CCP, cyclic citrullinated peptide; CEP, citrullinated enolase peptide; cit, citrullinated/citrullination; Fib, fibrinogen; HRCT, high-resolution CT; RF, rheumatoid factor; Vim, Vimentin.