Biomarkers | HLA-B27 (n=25) | HLA-B15 (n=12) | P value |
---|---|---|---|
CRP (mg/dL) | 16.9±22.1 | 11.1±15.3 | |
IL-1α (pg/mL) | 52.9±34.8 | 39.8±2.4 | |
IL-6 (pg/mL) | 53.0±47.5* | 42.5±39.2 | |
IL-17 (pg/mL) | 57.1±66.0 | 28.4±14.3 | <0.05 |
IL-23 (pg/mL) | 5.7±4.2 | 3.7±0.9 | <0.05 |
LBP (µ/mL) | 8.6±4.1 | 9.1±5.5 | |
MMP-3 (ng/mL) | 28.5±29.3 | 16.5±16.8 | |
SSA (pg/mL) | 1185±1034.6 | 1339.4±1107.2 | |
TNF-α (pg/mL) | 23.0±15.3 | 17.3±3.3† | |
ESR (mm/hour) | 21.4±16.3 | 19.8±13.4 |
*Two extreme outliers were excluded.
†One extreme outlier value (293 pg/mL) was excluded.
Results are expressed as mean±SD.
CRP, C reactive protein; ESR, erythrocyte sedimentation rate; IL, interleukin; LBP, lipopolysaccharide-binding protein; M-CSF, macrophage colony-stimulating factor; MMP-3, metalloproteinase-3; SAA, serum amyloid A; SpA, spondyloarthritis; TNF-α, tumour necrosis factor α.