Table 3

Levels of inflammatory serological biomarkers in patients with SpA according to the presence of HLA-B27 or HLA-B15

BiomarkersHLA-B27
(n=25)
HLA-B15
(n=12)
P value
CRP (mg/dL)16.9±22.111.1±15.3
IL-1α (pg/mL)52.9±34.839.8±2.4
IL-6 (pg/mL)53.0±47.5*42.5±39.2
IL-17 (pg/mL)57.1±66.028.4±14.3<0.05
IL-23 (pg/mL)5.7±4.23.7±0.9<0.05
LBP (µ/mL)8.6±4.19.1±5.5
MMP-3 (ng/mL)28.5±29.316.5±16.8
SSA (pg/mL)1185±1034.61339.4±1107.2
TNF-α (pg/mL)23.0±15.317.3±3.3†
ESR (mm/hour)21.4±16.319.8±13.4
  • *Two extreme outliers were excluded.

  • †One extreme outlier value (293 pg/mL) was excluded.

  • Results are expressed as mean±SD.

  • CRP, C reactive protein; ESR, erythrocyte sedimentation rate; IL, interleukin; LBP, lipopolysaccharide-binding protein; M-CSF, macrophage colony-stimulating factor; MMP-3, metalloproteinase-3; SAA, serum amyloid A; SpA, spondyloarthritis; TNF-α, tumour necrosis factor α.