Table 4

Frequency of ERAP SNP haplotypes in patients with SpA with HLA-B27 and HLA-B15

HaplotypesFrequenciesOR(95% CI)P value
HLA-B15HLA-B27+
Haplotypes formed by ERAP2 SNPs rs2549782, rs2248374 and rs2910686
TGT0.2010.0782.943(1.264 to 6.585)0.009
TGC0.0550.2274.483(1.524 to 13.187)0.003
CAT0.0200.1199.014(1.181 to 68.807)0.009
CAC0.6430.4991.750(0.968 to 3.162)0.077
CGC0.0160.0350.465(0.053 to 4.056)0.672
CGT0.0310.0132.406(0.332 to 17.45)0.584
TAT0.0190.0131.185(0.106 to 13.29)1.00
TAC0.0130.0151.185(0.106 to 13.29)1.00
Haplotypes formed by ERAP1 SNPs rs27044, rs17482078, rs10050860 and rs30187
GCCT0.4640.4421.117(0.627 to 1.990)0.708
CCCC0.3010.3300.895(0.480 to 1.668)0.729
GTTT0.1640.1141.533(0.680 to 3.456)0.301
GCCC0.0670.0770.774(0.240 to 2.495)0.783
CCCT0.0010.0160.785(0.080 to 7.684)1.00
  • ERAP, endoplasmic reticulum aminopeptidase; HLA, human leukocyte antigen; IL, interleukin; SpA, spondyloarthritis; SNP, single nucleotide polymorphism.