Frequency of ERAP SNP haplotypes in patients with SpA with HLA-B27 and HLA-B15
| Haplotypes | Frequencies | OR | (95% CI) | P value | |
|---|---|---|---|---|---|
| HLA-B15 | HLA-B27+ | ||||
| Haplotypes formed by ERAP2 SNPs rs2549782, rs2248374 and rs2910686 | |||||
| TGT | 0.201 | 0.078 | 2.943 | (1.264 to 6.585) | 0.009 |
| TGC | 0.055 | 0.227 | 4.483 | (1.524 to 13.187) | 0.003 |
| CAT | 0.020 | 0.119 | 9.014 | (1.181 to 68.807) | 0.009 |
| CAC | 0.643 | 0.499 | 1.750 | (0.968 to 3.162) | 0.077 |
| CGC | 0.016 | 0.035 | 0.465 | (0.053 to 4.056) | 0.672 |
| CGT | 0.031 | 0.013 | 2.406 | (0.332 to 17.45) | 0.584 |
| TAT | 0.019 | 0.013 | 1.185 | (0.106 to 13.29) | 1.00 |
| TAC | 0.013 | 0.015 | 1.185 | (0.106 to 13.29) | 1.00 |
| Haplotypes formed by ERAP1 SNPs rs27044, rs17482078, rs10050860 and rs30187 | |||||
| GCCT | 0.464 | 0.442 | 1.117 | (0.627 to 1.990) | 0.708 |
| CCCC | 0.301 | 0.330 | 0.895 | (0.480 to 1.668) | 0.729 |
| GTTT | 0.164 | 0.114 | 1.533 | (0.680 to 3.456) | 0.301 |
| GCCC | 0.067 | 0.077 | 0.774 | (0.240 to 2.495) | 0.783 |
| CCCT | 0.001 | 0.016 | 0.785 | (0.080 to 7.684) | 1.00 |
ERAP, endoplasmic reticulum aminopeptidase; HLA, human leukocyte antigen; IL, interleukin; SpA, spondyloarthritis; SNP, single nucleotide polymorphism.