Table 1

Polymorphisms of ERAP1 and ERAP2 genes in HLA-B27+ and HLA-B15+ patients with SpA

GenedbSNP*Chromosome allele positionAmino acid change(nucleotide variants)†LocationFunction
ERAP1rs27044chr5:96783148Q (CAA)/E (GAA)
Q (CAA)/stop (TAA)
ExonMissense
rs17482078chr5:96783162R (CGA)/P (CCA)
R (CGA)/Q (CAA)
ExonMissense
rs10050860chr5:96786506D (GAC)/N (AAC)ExonMissense
rs30187chr5:96788627K (AAG/R (AGG)
K (AAG)/M (ATG)
ExonMissense
ERAP2rs2549782ch5:96895296K (AAG)/N (AAT)
K (AAG)/N (AAC)
ExonMissense
rs2248374chr5:96900192(G)/(A)IntronG allele: mRNA decay
rs2910686chr5:96916885(C)/(T)Intron