Performance of carotid ultrasound parameters and Framingham risk scores in discriminating presence of CAD/obstructive CAD
| AUC | P value | Cut-off | Sensitivity (%) | Specificity (%) | |
|---|---|---|---|---|---|
| Presence of coronary artery disease (CAD) | |||||
| Carotid ultrasound parameters | |||||
| Mean cIMT | 0.67 | 0.007 | 0.62 mm | 76% | 60% |
| Maximum cIMT | 0.65 | 0.017 | 0.77 mm | 72% | 57% |
| Presence of carotid plaque | 0.57 | 0.061 | – | 44% | 70% |
| TPA | 0.58 | 0.063 | 11.95 mm2 | 25% | 94% |
| FRS and mFRS | |||||
| FRS | 0.76 | <0.001 | 5.2% | 81% | 62% |
| FRS high risk (FRS ≥20%) | 0.58 | 0.227 | 20% | 20% | 95% |
| mFRS | 0.76 | <0.001 | 7.9% | 81% | 62% |
| mFRS high risk (mFRS ≥20%) | 0.66 | 0.010 | 20% | 43% | 89% |
| Combination model | |||||
| FRS >5% & mean cIMT >0.62 mm | 0.71 | 0.001 | – | 67% | 76% |
| mFRS >8% & mean cIMT >0.62 mm | 0.74 | <0.001 | – | 67% | 81% |
| Presence of obstructive CAD | |||||
| Carotid ultrasound parameters | |||||
| Mean cIMT | 0.80 | 0.004 | 0.73 mm | 78% | 78% |
| Maximum cIMT | 0.71 | 0.037 | 0.78 mm | 100% | 45% |
| Presence of carotid plaque | 0.60 | 0.352 | – | 56% | 65% |
| TPA | 0.64 | 0.164 | 1.25 mm2 | 44% | 87% |
| FRS and mFRS | |||||
| FRS | 0.76 | 0.012 | 10.7% | 78% | 65% |
| FRS ≥20% | 0.61 | 0.300 | 20% | 33% | 88% |
| mFRS | 0.76 | 0.012 | 16.1% | 78% | 65% |
| mFRS ≥20% | 0.64 | 0.159 | 20% | 56% | 73% |
| Combination model | |||||
| FRS >10% & mean cIMT >0.73 mm | 0.71 | 0.045 | – | 56% | 85% |
| mFRS >16% and mean cIMT >0.73 mm | 0.71 | 0.045 | – | 100% | 59% |
Bold values indicate p <0.05.
cIMT, carotid intima media thickness; FRS, Framingham risk score; mFRS, Modified Framingham risk score; TPA, total plaque area.