Sex stratified, multivariate Cox regression analysis with HR for incident OA of the CMC-1 joint in relation to BMI as a continuous variable and for overweight and obese participants with normal weight participants as reference
| Model I* | Model II† | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Men | ||||
| BMI continuous‡ | 1.12 (1.09–1.15) | <0.001 | 1.12 (1.09–1.15) | <0.001 |
| Normal weight | Reference | – | Reference | – |
| Overweight | 1.52 (1.25–1.85) | <0.001 | 1.55 (1.27–1.90) | <0.001 |
| Obesity | 3.41 (2.58–4.49) | <0.001 | 3.57 (2.68–4.77) | <0.001 |
| Women | ||||
| BMI continuous‡ | 1.05 (1.03–1.08) | <0.001 | 1.06 (1.03–1.08) | <0.001 |
| Normal weight | Reference | – | Reference | – |
| Overweight | 1.23 (0.97–1.57) | =0.090 | 1.27 (0.98–1.63) | =0.052 |
| Obesity | 1.88 (1.38–2.57) | <0.001 | 1.98 (1.44–2.73) | <0.001 |
*Adjusted for age at study entry.
†Adjusted for age at study entry, hypertension, prevalent diabetes, manual work and smoking.
‡HR expressed as per one unit increase of BMI.
BMI, body mass index; CMC-1, first carpometacarpal joint; OA; osteoarthritis.