Table 2

Univariable analysis. Variables associated with anxiety and/or depression scores at baseline, month 6 and month 12. All variables are at baseline unless otherwise indicated by ¶. Significant values are highlighted in bold

Anxiety score
	Baseline		6 months		12 months
Categorical factors	P value		P value		P value
Female gender	0.002		0.212		0.214
Smoking	0.124		0.008		0.039
Unemployment*	0.001		<0.0001		<0.0001
Marital status†	0.04		0.004		0.01
Continuous variables	R	P value	r	P value	r	P value
Age	−0.187	<0.0001	−0.158	<0.0001	−0.131	0.001
BMI	0.005	0.897	−0.044	0.289	−0.084	0.044
Anxiety baseline	NA	NA	0.691	<0.0001	0.632	<0.0001
Depression baseline	0.681	<0.0001	0.507	<0.0001	0.443	<0.0001
Tender joint count (0–28)¶	0.169	<0.0001	0.314	<0.0001	0.306	<0.0001
Swollen joint count (0–28)¶	0.011	0.759	0.161	<0.0001	0.184	<0.0001
Patient global VAS‡,¶	0.210	<0.0001	0.397	<0.0001	0.387	<0.0001
HAQ¶	0.339	<0.0001	0.409	<0.0001	0.446	<0.0001
Depression score
	Baseline		6 months		12 months
Categorical factors	P value		P value		P value
Smoking	0.343		0.021		0.002
Unemployment	0.001		<0.0001		<0.0001
Marital status	0.008		0.007		0.03
Anti-CCP negative	0.013		0.431		0.900
Glucocorticoids	NA		0.017**		0.005††
Continuous variables	R	P value	r	P value	r	P value
Age	−0.101	0.004	−0.028	0.494	−0.012	0.770
BMI	0.075	0.037	0.051	0.224	0.058	0.183
Alcohol units§	−0.107	0.002	−0.037	0.332	−0.057	0.160
Anxiety baseline	0.681	<0.0001	0.488	<0.0001	0.423	<0.0001
Depression baseline	NA	NA	0.602	<0.0001	0.519	<0.0001
Tender joint Count (0–28)¶	0.263	<0.0001	0.361	<0.0001	0.388	<0.0001
Swollen joint Count (0–28)¶	0.117	0.0007	0.265	<0.0001	0.276	<0.0001
Patient global VAS¶	0.328	<0.0001	0.500	<0.0001	0.522	<0.0001
HAQ¶	0.541	<0.0001	0.594	<0.0001	0.609	<0.0001
ESR¶	0.116	0.016	0.077	0.128	0.130	0.029
CRP¶	0.163	<0.0001	0.152	<0.0001	0.112	0.004

*ANOVA test, reference group employed and retired individuals.
†Married or living with partner compared to individuals who are single.
‡Used for DAS28 calculation.
§Average alcohol units/week.
¶At time point of interest.
**Oral.
††Intramuscular. BMI, body mass index; NA, not applicable; CCP, cyclic citrullinated peptide; DAS, disease activity score; VAS, visual analogue scale; HAQ, health assessment questionnaire; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein. Benjamini-Hochberg correction did not affect the statistical significance of the reported values at any of the time-points examined. See table 3 for more details about categorical variables.