Table 4

Multivariable linear regression analysis. Variables associating with high anxiety and/or depression scores at baseline, month 6 and month 12. All variables at baseline unless otherwise indicated by‡

Anxiety score
	Baseline		6 months		12 months
Covariates	P value	Beta	P value	Beta	P value	Beta
Age	0.001	−0.217	0.669	−0.024	0.960	−0.003
BMI	0.669	−0.020	0.015	−0.097	0.001	− 0.141
Anxiety baseline	NA	NA	<0.0001	0.609	<0.0001	0.555
Patient global VAS*^,‡	0.261	0.061	0.008	0.135	0.009	0.139
HAQ‡	<0.0001	0.307	0.006	0.146	0.001	0.208
Depression score
	Baseline		6 months		12 months
Covariates	P value	Beta	P value	Beta	P value	Beta
Age	0.029	−0.128	0.477	0.039	0.108	−0.074
Gender	0.392	0.039	0.016	−0.689	0.153	−0.436
Marital status†	0.022	0.097	0.974	−0.001	0.716	0.015
Baseline depression score	NA	NA	<0.0001	0.352	<0.0001	0.303
Baseline anxiety score	NA	NA	0.002	0.165	0.04	0.121
Patient global VAS‡	0.101	0.082	0.012	0.125	0.010	0.136
HAQ‡	<0.001	0.486	<0.0001	0.327	<0.0001	0.372
CRP levels‡	0.508	0.034	0.009	0.133	0.003	0.151

*Used for DAS28 calculation.
†Married or living with partner compared to individuals who are single.
‡At time point of interest. BMI, body mass index; NA, not applicable; VAS, visual analogue scale; HAQ, health assessment questionnaire; CRP, C-reactive protein.
Significant values are shown in bold.