All starters | Matched starters | |||||||
---|---|---|---|---|---|---|---|---|
Hydroxychloroquine(N=2270) | Other csDMARD (N=4522) | Hydroxy-chloroquine (N=1534) | Other csDMARD (N=1534) | |||||
Mean (SD) | Mean (SD) | Std. Diff.† | Mean (SD) | Mean (SD) | Std. Diff. | |||
Age | 60.05 (13.99) | 60.38 (13.44) | 0.084 | 60.11 (14.30) | 59.97 (13.69) | 0.010 | ||
Duration of RA‡ | 5.66±8.00 | 5.45±8.36 | 0.025 | 5.5±8.27 | 5.51±7.77 | 0.002 | ||
CDAI§ | 12.7±10.80 | 17.15±13.77 | 0.359 | 13.38±11.24 | 13.54±11.37 | 0.014 | ||
BMI | 29.53±6.96 | 29.84±6.94 | 0.045 | 29.54±6.96 | 29.77±7.03 | 0.033 | ||
N(%) | N(%) | N(%) | N(%) | |||||
Gender | 0.077 | 0.012 | ||||||
Men | 523 (23.2) | 1193 (26.5) | 368 (24) | 360 (23.5) | ||||
Women | 1730 (76.8) | 3303 (73.5) | 1166 (76) | 1174 (76.5) | ||||
Hx of CVD | 311 (13.7) | 563 (12.5) | 0.037 | 212 (13.8) | 216 (14.1) | 0.008 | ||
Hx of Diabetes | 228 (10) | 495 (10.9) | 0.029 | 156 (10.2) | 162 (10.6) | 0.013 | ||
Smoking Status | 0.004 | 0.011 | ||||||
Never | 1146 (51.1) | 2256 (50.6) | 795 (52.2) | 783 (51.3) | ||||
Previous | 723 (32.3) | 1478 (33.1) | 478 (31.4) | 491 (32.2) | ||||
Current | 372 (16.6) | 728 (16.3) | 251 (16.5) | 251 (16.5) | ||||
Prednisone Dosage | 0.184 | 0.013 | ||||||
None | 1665 (74) | 3040 (68.4) | 1112 (72.5) | 1113 (72.6) | ||||
<7.5 mg | 421 (18.7) | 780 (17.5) | 278 (18.1) | 289 (18.8) | ||||
≥7.5 mg | 165 (7.3) | 626 (14.1) | 144 (9.4) | 132 (8.6) | ||||
Number csDMARD | 0.884 | 0.022 | ||||||
One | 1083 (47.7) | 3878 (85.8) | 973 (63.4) | 989 (64.5) | ||||
2+ | 1187 (52.3) | 644 (14.2) | 561 (36.6) | 545 (35.5) | ||||
Hx of Serious Infection¶ | 156 (6.9) | 254 (5.6) | 0.052 | 105 (6.8) | 97 (6.3) | 0.021 |
*csDMARD medications refers to conventional disease-modifying antirheumatic drugs.
†Std. Diff. is the standardised difference between the two treatment groups.
‡Duration of RA refers to duration of rheumatoid arthritis since initial diagnosis.
§CDAI refers to Clinical Disease Activity Index-a clinical measurement of RA disease severity.
¶Hx of Serious Infection refers to history of serious upper respiratory infection, bronchitis or pneumonia prior to starting hydroxychloroquine or csDMARD medication.