Baseline predictors for continued fatigue vs improved (logistic regression analyses)
| Univariate | Multivariable | |
|---|---|---|
| Variables | OR (95% CI)† | OR (95% CI) |
| Age (years) | 1.01 (0.98–1.05) | 1.02 (0.98–1.06) |
| Female gender | 1.79 (0.52–6.15) | 1.57 (0.34–7.35) |
| Higher Education | 0.30 (0.11–0.81)* | |
| Anti-CCP positive | 5.51 (1.02–29.60)* | |
| RF positive | 1.72 (0.56–5.29) | |
| Disease duration | 1.03 (0.98–1.10) | |
| RA disease activity baseline | ||
| Swollen joints (28) | 1.01 (0.92–1.10) | |
| CRP (mg/L) | 0.99 (0.97–1.01) | |
| Calprotectin | 0.77 (0.57–1.04)¤ | |
| Sum PD | 0.98 (0.95–1.02) | |
| Sum BM | 0.99 (0.97–1.02) | |
| PROMs | ||
| Patient global VAS | 1.04 (1.02–1.07)** | 1.03 (1.01–1.06)* |
| Tender joints 28 | 1.21 (1.08–1.35)* | 1.19 (1.04–1.35)* |
| RAID sleep | 1.26 (1.06–1.51)* | |
| Widespread pain | 1.08 (0.98–1.20) | |
| HADS anxiety | 1.17 (1.03–1.33)* | 1.23 (1.05–1.45)* |
| HADS depression | 1.26 (1.06–1.49)* | |
| Pain Catastrophizing | 1.23 (0.89–1.69) | |
† Univariate model adjusted for age and gender.
¤p<0.10 *p≤0.05 **p≤0.001.
No fatigue: Fatigue ≤3 at baseline and at 4/5 visits. Improved fatigue: Fatigue ≥4 at baseline, but ≤3 at 6- and 12-months visit. Continued: Fatigue ≥4 at 5/6 visits.
GS, Grey scale; HADS, Hospital anxiety and depression scale; PD, Power Doppler; VAS, Visual analogue scale.