Table 3

Predictors of renal damage. Patients with biopsy-proven lupus nephritis (n=241)

UnivariableMultivariable
HR (95% CI)p valueHR (95% CI)p value
Age at nephritis diagnosis0.99 (0.97–1.01)0.275
Gender (male)1.11 (0.66–1.86)0.687
Residence (rural)0.64 (0.30–1.38)0.253
Ethnicity
 CaucasianRef.
 Mestizo1.02 (0.68–1.53)0.930
 Afro Latin-American1.53 (0.85–2.770)0.159
 Others0.46 (0.11–1.92)0.288
SES
 High0.21 (0.05–0.87)0.0320.24 (0.06–0.897)0.045
 Medium0.69 (0.46–1.03)0.0720.71 (0.48–1.07)0.101
 LowRef.Ref.
Early treatment response0.54 (0.32–0.94)0.0280.67 (0.38–1.16)0.151
Proteinuria2.01 (1.0564–3.85)0.036
Low complement1.28 (0.88–1.86)0.204
Anti-dsDNA0.91 (0.63–1.32)0.228
Creatinine level1.21 (1.05–1.38)0.007
Hypertension1.91 (1.29–2.83)0.0011.75 (1.18–2.61)0.006
Renal component of SLEDAI1.41 (0.95–2.09)0.086
Prednisone dose1.00 (0.99–1.66)1.019
Immunosuppressive drugs use1.01 (0.69–1.47)0.958
Antimalarial use0.67 (0.426–1.08)0.101
Non-proliferative biopsy0.748 (0.49–1.14)0.178
  • Anti-dsDNA, anti-double-stranded DNA; SES, Socioeconomic status; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.