Reliability and responsiveness of the NRS questions of RAID from the rainbow study
| RAID NRS | Screening | Baseline (2 weeks after screening) | 12 weeks (after baseline) | Reliability screening baseline (ICC, 95% CI) (n=108) | Sensitive to change baseline 12 weeks (SRM, 95% CI) (n=97) |
| Tender joint count | 10.3 (5.9) | 10.7 (5.8) | 4.2 (4.8) | 0.90 (0.85 to 0.93) | 1.18 (0.90 to 1.38) |
| Swollen Joint Count | 8.2 (9.8) | 8.6 (4.1) | 2.3 (2.6) | 0.89 (0.83 to 0.92) | 1.82 (1.59 to 2.05) |
| PGA | 6.6 (1.7) | 6.5 (1.9) | 3.3 (2.3) | 0.63 (0.50 to 0.73) | 1.35 (1.01 to 1.63) |
| DAS28(3 v)-ESR | 5.1 (0.8) | 5.1 (0.8) | 3.3 (1.1) | 0.93 (0.90 to 0.95) | 1.80 (1.50 to 2.10) |
| Pain | 6.6 (1.8) | 6.5 (1.8) | 3.1 (2.3) | 0.64 (0.51 to 0.74) | 1.34 (1.01 to 1.64) |
| Function | 6.4 (1.9) | 6.3 (2.0) | 3.2 (2.4) | 0.69 (0.58 to 0.78) | 1.21 (0.89 to 1.49) |
| Fatigue | 6.4 (2.3) | 6.2 (2.3) | 3.4 (2.7) | 0.80 (0.72 to 0.86) | 1.16 (0.89 to 1.36) |
| Emotional Well-being | 5.5 (2.5) | 5.3 (2.4) | 2.8 (2.4) | 0.75 (0.65 to 0.82) | 1.04 (0.79 to 1.26) |
| Physical Well-being | 6.3 (2.0) | 6.2 (1.9) | 3.1 (2.5) | 0.78 (0.70 to 0.85) | 1.25 (0.97 to 1.50) |
| Sleep Disturbance | 5.3 (2.9) | 5.5 (2.8) | 2.9 (2.7) | 0.83 (0.76 to 0.88) | 0.93 (0.73 to 1.13) |
| Coping | 4.9 (2.2) | 4.8 (2.0) | 2.6 (2.2) | 0.64 (0.52 to 0.74) | 0.97 (0.63 to 1.22) |
Results are presented as Mean (SD) at each time point. CI obtained through bootstrapping method. ICC >0.8 was considered excellent. SRM >0.8 was considered as responsive.
DAS28(3v)-ESR, Disease activity Score, 3 variables with erythrocyte sedimentation rate; ICC, intra-class correlation; NRS, numerical rating scale; PGA, patient global assessment ; SRM, standardised response mean.