Author | Study type | Population | Blood type distribution | Other findings | RoB |
Rhesus and ABO | |||||
Ellinghaus et al17 | GWAS | 1980 severe COVID-19 vs 2381 HD Italian Spanish | NA |
| Low |
HLA | |||||
Novelli et al16 | Sequencing and genotyping of HLA genes | 99 COVID-19 vs 1017 normal Italian subjects | Haplotypes more prevalent in COVID-19 B*27:07 DRB1*15:01 DQB1*06:02 | p value vs HD 0.004 0.048 0.016 | Unclear |
Ellinghaus et al17 | GWAS | 1980 severe COVID-19 vs 2381 HD Italian Spanish |
| High | |
Genes encoding molecules involved in the host immune response | |||||
Zhang et al12 | Sequencing and genotyping of IFITM3 rs12252 sequence | 80 COVID-19 (56 mild, 24 severe) vs Beijing population (International Genome Sample Resource) |
| Unclear | |
Cabrera-Marante et al14 | Sequencing and genotyping of PRF1 rs35947132 (A91V) sequence | 22 severe young COVID-19 vs 22 HD (14 Latin-American, 7 Spanish and 1 Polish) |
| High | |
Ellinghaus et al17 | GWAS | 1980 severe COVID-19 vs 2381 HD Italian Spanish |
| High | |
Zhang et al11 | RNA Seq | 659 life-threatening COVID-19 pneumonia vs 534 asymptomatic or benign SARS-CoV-2 infection |
| Low | |
Pairo-Castineira et al13 | GWAS | 2244 critical (ICU) COVID-19 vs 11220 HD |
| Low | |
ACE-2 | |||||
Benetti et al19 | Whole exome seq | 131 COVID-19 vs 258 HD |
| Unclear | |
Novelli et al16 | Whole exome seq | 131 hospitalised COVID-19 vs 1000 HD |
| Unclear | |
Gomez et al20 | ACE2 gene seq and SNP assessment | 204 COVID-19 (137 non-severe and 67 severe) vs 536 HD |
| Unclear | |
Ellinghaus et al17 | GWAS | 1980 severe COVID-19 vs 2381 HD Italian Spanish |
| High |
GWAS, genome-wide association study; HD, healthy donor; HLA, human leucocyte antigens; JAK, Janus kinase; NA, not available; RoB, risk of bias; SNP, single nuclear polymorphism; TYK, tyrosine kinase.