Results from Cox regression analyses for all-cause mortality
| Variable | HR (95% CI) | P value | |
| Step1a | RA (univariable) | Control: reference | |
| RA: 1.21 (1.01 to 1.45) | 0.036 | ||
| Step1b | eCRF-dichotomous (univariable) | eCRF above median: reference | |
| eCRF below median: 1.19 (1.14 to 1.23) | <0.001 | ||
| Step 2 | RA and eCRF-dichotomous (bivariable) | Control: reference | |
| RA: 1.15 (0.96 to 1.37) | 0.12 | ||
| eCRF above median: reference | |||
| eCRF below median: 1.19 (1.14 to 1.23) | <0.001 | ||
| Step 3 | RA and eCRF-dichotomous, adjusted for hypertension, BMI, smoking, total cholesterol, diabetes and creatinine | Control: reference | |
| RA: 1.10 (0.93 to 1.32) | 0.27 | ||
| eCRF above median: reference | |||
| eCRF below median: 1.18 (1.13 to 1.23) | <0.001 | ||
| Sensitivity analysis 1 | RA and eCRF-tertiles, adjusted for hypertension, BMI, smoking, total cholesterol, diabetes and creatinine | Control: reference | |
| RA: 1.09 (0.91 to 1.30) | 0.34 | ||
| eCRF higher tertile: reference | |||
| eCRF middle tertile: 1.12 (1.07 to 1.17) | <0.001 | ||
| eCRF lower tertile: 1.24 (1.18 to 1.31) | <0.001 | ||
| Sensitivity analysis 2 | RA and eCRF-continuous, adjusted for hypertension, BMI, smoking, total cholesterol, diabetes and creatinine | Control: reference | |
| RA: 1.10 (0.93 to 1.32) | 0.25 | ||
| eCRF-continuous: 0.99 (0.989 to 0.997) | 0.001 | ||
| Sensitivity analysis 3 | RA and eCRF-dichotomous, adjusted for hypertension, BMI, smoking, total cholesterol, diabetes, creatinine and previous cardiovascular disease | Control: reference | |
| RA: 1.08 (0.91 to 1.29) | 0.39 | ||
| eCRF above median: reference | |||
| eCRF below median: 1.18 (1.13 to 1.23) | <0.001 |
Hypertension: systolic blood pressure ≥140 mm Hg and/or diastolic bloodpressure ≥90 mm Hg and/or use of antihypertensive medication. Previous cardiovascular disease: self-reported stroke and/or angina and/or myocardial infarction. Diabetes: self-reported diabetes and/or use of antidiabetic medication and/or having a non-fasting blood-glucose level >11 mmol/L.
BMI, body mass index; eCRF, estimated cardiorespiratory fitness; eCRF-continuous, eCRF a a continuous variable; eCRF-dichotomous, eCRF categorised as above or below the median eCRF for each participant's sex and age group (<40 years, 40-59 years, > 60 years); eCRF-tertiles, cCRF categorised into higher, middle and lower eCRF tertile for each participant's sex and age group; RA, rheumatoid arthritis.