Prevalence over the last year and relative risk for the entire study duration for all 26 autoimmune diseases and associated conditions investigated in patients with JIA compared with the GP population
| Disease | Prevalence over the last year | Log risk ratio (95% CI) | |
| JIA n=1332 | GP n=692 444* | ||
| Autoimmune diseases | |||
| Addison disease | 0.83 n=11 | 0.15 n=1058 | 1.65 (1.02 to 2.21) |
| Alopecia areata | 0 | 0.05 n=313 | NA |
| Autoimmune/Hashimoto’s thyroiditis | 1.21 n=16 | 0.12 n=854 | 2.25 (1.72 to 2.71) |
| Graves’ disease | 0.08 n=1 | 0.03 n=197 | 0.38 (–2.77 to 2.26) |
| Morphoea | 0.91 n=12 | 0.04 n=258 | 3.15 (2.54 to 3.70) |
| Multiple sclerosis | 0.08 n=1 | 0.006 n=44 | 1.90 (–1.27 to 3.83) |
| Myasthenia gravis | 0 | 0.007 n=46 | NA |
| Pernicious anaemia | 0 | 0.001 n=7 | NA |
| Primary biliary cirrhosis | 0 | 0.004 n=27 | NA |
| Takayasu arteritis | 0.08 n=1 | 0.01 n=69 | 1.45 (–1.71 to 3.35) |
| Type 1 diabetes mellitus | 1.28 n=17 | 0.35 n=2451 | 1.25 (0.75 to 1.70) |
| Vitiligo | 0.38 n=5 | 0.06 n=402 | 1.76 (0.74 to 2.59) |
| Associated conditions | |||
| Autoimmune disease NEC | 0.61 n=8 | 0.04 n=307 | 2.55 (1.78 to 3.21) |
| Chronic glomerulonephritis | 0.08 n=1 | 0.02 n=139 | 0.73 (–2.45 to 2.64) |
| Chronic urticaria | 3.68 n=49 | 2.05 n=14 178 | 0.58 (0.28 to 0.84) |
| Episcleritis/scleritis | 0.38 n=5 | 0.01 n=98 | 3.18 (2.14 to 4.03) |
| Erythema nodosum | 0.08 n=1 | 0.01 n=95 | 1.12 (–2.03 to 3.02) |
| Haemolytic anaemia | 0.07 n=1 | 0.06 n=410 | –0.36 (–3.49 to 1.54) |
| Immune thrombocytopenia purpura | 0.15 n=2 | 0.08 n=540 | 0.40 (–1.42 to 1.68) |
| Leukocytoclastic vasculitis | 0.15 n=2 | 0.002 n=14 | 4.08 (2.19 to 5.49) |
| Myositis | 10.14 n=135 | 0.87 n=6002 | 2.46 (2.28 to 2.62) |
| Pulmonary fibrosis/interstitial lung disease | 1.13 n=15 | 0.04 n=261 | 3.37 (2.80 to 3.86) |
| Raynaud’s syndrome | 1.43 n=19 | 0.05 n=367 | 3.27 (2.79 to 3.71) |
| Sjögren’s syndrome/sicca syndrome | 0.23 n=3 | 0.004 n=28 | 3.86 (2.40 to 5.01) |
| Thrombocytopenia purpura | 0.07 n=1 | 0.02 n=163 | 0.57 (–2.61 to 2.46) |
| Vasculitis | 0.60 n=8 | 0.01 n=97 | 3.71 (2.90 to 4.37) |
Prevalence rate calculated by averaging the patient population at the end of the last calendar year and at the end of the previous year.
Autoimmune diseases that had a significantly higher prevalence in the JIA cohort compared with the GP cohort are shown in bold.
*Denominator is for the whole GP patient population, including those who did not have a protocol-specified autoimmune disease.
CI, confidence interval; GP, general paediatric; JIA, juvenile idiopathic arthritis; NA, not applicable; NEC, not elsewhere classified.