Table 1

Univariable and multivariable associations of MRI-inflammation and DAS at inclusion and fatigue at inclusion and associations of MRI-inflammation and DAS over time with fatigue course over time

UnivariableP valueMRI-inflammation corrected for potential confoundersP valueDAS corrected for potential confoundersP value
Baseline
Total MRI-inflammation−0.27 (−0.58 to 0.04)0.08−0.01 (−0.36 to 0.33)0.94
DAS1.17 (0.80 to 1.53)<0.0011.22 (0.84 to 1.59)<0.001
ACPA0.76 (−1.29 to −0.22)0.0060.80 (−1.33 to −0.26)0.0040.60 (−1.13 to −0.09)0.023
Age in years0.02 (−0.04 to 0.00)0.031−0.01 (−0.04 to 0.01)0.160.02 (−0.04 to 0.00)0.021
Female gender1.21 (0.67 to 1.75)<0.0011.21 (0.65 to 1.76)<0.0011.04 (0.50 to 1.58)<0.001
Over time
Total MRI-inflammation−0.01 (−0.29 to 0.27)0.95−0.01 (−0.30 to 0.28)0.96
DAS1.03 (0.78 to 1.28)<0.0011.01 (0.77 to 1.26)<0.001
ACPA0.10 (−0.56 to 0.76)0.770.09 (−0.58 to 0.76)0.79−0.06 (−0.66 to 0.55)0.86
Age in years−0.02 (−0.04 to 0.01)0.160.00 (−0.03 to 0.03)0.95−0.02 (−0.04 to 0.00)0.13
Female gender1.27 (0.59 to 1.94)<0.0011.49 (0.78 to 2.20)<0.0010.79 (0.15 to 1.43)0.016
  • Bold results indicate p<0.05.

  • ACPA, anticitrullinated protein antibodies; DAS, Disease Activity Score.