Estimates of subsequent change of MRI-inflammation, DAS and fatigue
| Subsequent change | Standardised regression coefficient | P value |
| MRI-inflammation precedes fatigue | 0.17 (0.01 to 0.34) | 0.039 |
| Fatigue precedes MRI-inflammation | 0.04 (−0.12 to 0.20) | 0.63 |
| DAS precedes fatigue | 0.19 (0.04 to 0.34) | 0.012 |
| Fatigue precedes DAS | 0.10 (−0.07 to 0.27) | 0.23 |
Analyses were performed with the hypothesis that if inflammation decrease precedes fatigue decrease, inflammation decrease (0–12 months) will associate with fatigue decrease (12–24 months) but not the other way around. Standardised regression coefficients of change of one inflammatory feature to subsequent change in another inflammatory feature, corrected for the simultaneous pattern and previous values of those inflammatory features, with 95% CI. Bold: significant estimate (p<0.05).
DAS, Disease Activity Score.