Analyses of parameters (including baseline CRP levels) associated with radiographic spinal progression (worsening of mSASSS by ≥2 points after 2 years) in axial spondyloarthritis stratified by the FGB rs1800790G>A or PFGB rs1800790G>A
| Genotype | CRPbaseline ≥10 mg/L OR (95% CI) | Syndesmophytes OR (95% CI) | Current smoking OR (95% CI) |
| FGB rs1800790G>A | |||
| GG (wild-type) (n=124) | 5.71† (1.69 to 19.3) | 4.84 (1.44 to 16.3) | 1.49 (0.47 to 4.72) |
| A-allele carrier (n=84) | 0.38† (0.06 to 2.53) | 14.2 (2.31 to 87.2) | 6.69 (1.24 to 36.2) |
| PFGB rs1800790G>A | |||
| Absent (n=156) | 4.98* (1.57 to 15.7) | 5.3 (1.76 to 16.0) | 2.00 (0.70 to 5.67) |
| Present (n=52) | 0.26* (0.03 to 2.34) | 13.3 (1.69 to 104.1) | 3.91 (0.48 to 31.6) |
Logistic regression analyses were performed after stratification for absence or presence of the indicated genotype constellation using CRPbaseline ≥10 mg/L, syndesmophytes at baseline and current smoking. All analyses were adjusted for sex and for presence of definite radiographic sacroiliitis according to modified New York criteria.
*P for homogeneity: 0.024.
†P for homogeneity: 0.041.
CRPbaseline, level of C-reactive protein at baseline; FGB, β-fibrinogen; mSASSS, modified Stoke Ankylosing Spondylitis Spinal Score.