Analysis of parameters associated with radiographic spinal progression (worsening of mSASSS by ≥2 points after 2 years) in axial spondyloarthritis stratified by A2AP Arg6Trp, F13A Val34Leu or F13B His95Arg genotype
| Genotype | CRPmean≥10 mg/L OR (95% CI) | Syndesmophytes OR (95% CI) | Current smoking OR (95% CI) |
| A2AP Arg6Trp | |||
| 6Arg/Arg (n=116) | 1.47‡ (0.35 to 6.19) | 4.80 (1.16 to 19.9) | 6.59 (1.73 to 25.1) |
| 6Trp (n=93) | 5.86‡ (1.63 to 21.0) | 5.76 (1.55 to 21.4) | 0.74 (0.17 to 3.11) |
| F13A Val34Leu | |||
| 34Val/Val (n=117) | 1.72* (0.52 to 5.71) | 4.65 (1.41 to 15.3) | 1.08 (0.33 to 3.52) |
| 34Leu (n=91) | 8.72* (1.69 to 45.1) | 9.47 (1.76 to 51.0) | 5.15 (1.10 to 24.0) |
| F13B His95Arg | |||
| 95His/His (n=142) | 2.36† (0.66 to 8.43) | 15.1 (3.31 to 69.3) | 4.11 (1.26 to 13.4) |
| 95Arg (n=67) | 6.84† (1.51 to 30.9) | 2.61 (0.56 to 12.1) | 1.14 (0.25 to 5.25) |
Logistic regression analyses were performed after stratification as indicated using CRPmean≥10 mg/L, syndesmophytes at baseline and current smoking. All analyses were adjusted for sex and for presence of definite radiographic sacroiliitis according to modified New York criteria.
*P for homogeneity: 0.21.
†P for homogeneity: 0.30.
‡P for homogeneity: 0.18.
A2AP, α2-antiplasmin; CRPmean, time-averaged level of C-reactive protein; F13A, factor XIII A-subunit; F13B, factor XIII B-subunit; mSASSS, modified Stoke Ankylosing Spondylitis Spinal Score.