Analyses of parameters associated with radiographic spinal progression (worsening of mSASSS by ≥2 points after 2 years) in axial spondyloarthritis stratified by the prothrombotic genotype constellations PFGB rs1800790G>A and PFGA rs2070016T>C
| Genotype | CRPmean≥10 mg/L OR (95% CI) | Syndesmophytes OR (95% CI) | Current smoking OR (95% CI) |
| PFGB rs1800790G>A | |||
| Absent (n=156) | 6.31† (2.09 to 19.0) | 4.41 (1.49 to 13.1) | 1.88 (0.65 to 5.41) |
| Present (n=52) | 0.50† (0.06 to 4.00) | 12.4 (1.53 to 100.8) | 3.71 (0.50 to 27.2) |
| PFGA rs2070016T>C | |||
| Absent (n=172) | 5.58* (1.97 to 15.8) | 5.42 (1.90 to 15.4) | 1.53 (0.56 to 4.22) |
| Present (n=36) | 0.40* (0.02 to 6.38) | 16.3 (0.78 to 338.9) | 9.76 (0.83 to 114.5) |
Logistic regression analyses were performed after stratification for absence or presence of the indicated prothrombotic genotype constellation using CRPmean≥10 mg/L, syndesmophytes at baseline and current smoking. All analyses were adjusted for sex and for presence of definite radiographic sacroiliitis according to modified New York criteria.
*P for homogeneity: 0.094.
†P for homogeneity: 0.048.
CRPmean, time-average level of C-reactive protein; FGA, α-fibrinogen; FGB, β-fibrinogen; mSASSS, modified Stoke Ankylosing Spondylitis Spinal Score.