Analysis of parameters associated with radiographic spinal progression (worsening of mSASSS by ≥2 points after 2 years) in axial spondyloarthritis stratified by FGB rs1800790G>A genotype
| Parameters | Unstratified OR (95% CI) (n=208) | FGB rs1800790GG (wild-type) OR (95% CI) (n=124) | FGB rs1800790A (A-allele carriage) OR (95% CI) (n=84) |
| CRPmean | |||
| >6 mg/L (model 1) | 2.56 (1.03 to 6.35) | 5.64† (1.56 to 20.3) | 0.99† (0.20 to 4.92) |
| ≥10 mg/L (model 2) | 3.32 (1.35 to 8.13) | 6.86* (2.08 to 22.6) | 0.83* (0.14 to 4.84) |
| Syndesmophytes | |||
| Model 1 | 4.70 (1.92 to 11.5) | 3.25 (1.00 to 10.6) | 12.2 (2.12 to 70.5) |
| Model 2 | 4.82 (1.96 to 11.9) | 3.47 (1.06 to 11.4) | 12.7 (2.14 to 75.2) |
| Current smoking | |||
| Model 1 | 2.37 (0.99 to 5.67) | 1.39 (0.45 to 4.31) | 6.08 (1.18 to 31.2) |
| Model 2 | 2.26 (0.93 to 5.48) | 1.51 (0.48 to 4.77) | 6.28 (1.19 to 33.2) |
Logistic regression analyses were performed in two models using either CRPmean>6 mg/L (model 1) or CRPmean≥10 mg/L (model 2). Syndesmophytes at baseline and current smoking were used as covariables. All analyses were adjusted for sex and for presence of definite radiographic sacroiliitis according to modified New York criteria. Data of unstratified analysis as well as after stratification for FGB rs1800790GG and FGB rs1800790A are presented.
*P for homogeneity: 0.11.
†P for homogeneity: 0.17.
CRPmean, time-average level of C-reactive protein; FGB, β-fibrinogen; mSASSS, modified Stoke Ankylosing Spondylitis Spinal Score.