Reference | Recruited, n | Randomised, n | T-score (mean) | Spine MRI | Treated vertebral fractures, n (%) | Pain duration (vertebroplasty group) | % in patients | Baseline VAS | Cement volume (mL) |
Buchbinder et al20 | 468 | 78 | T≤−2.5 Lumbar spine 62% Femoral neck 38% | Yes | 1 (82) 2 (18) | Median 9 weeks (3.8–13) | ? | 7.4±2.1 7.1±2.3 | 2.8±1.2 (1.2–5.5) |
Kallmes et al21 | 1813 | 131 | NA | No | 1 (71) 2 (19) 3 (10) | Mean 16 weeks (10–36) | 0 | 6.9±2.0 7.2±1.8 | ? |
Clark et al22 (VAPOUR) | 302 | 120 | −4.3±1.0 | Yes | 1 (84) 2 (16) | Mean (weeks) 2.8±1.6 | 59 | 8.1±1.8 8.2±1.5 | 7.5±2.8 (4.7–10.3) |
Firanescu et al23 (VERTOS IV) | 1280 | 180 | −2.4±1.0 | Yes | 1 (78) 2 (17) 3 (6) | Median (days) 43 (29–52) | 0 | 7.7±1.4 7.9±1.6 | 5.1±1.8 (1–11) |
NA, not available; VAS, Visual Analogue Scale.