Outcome | Adj. mean HCQ | 95% CI HCQ | Adj. mean PBO | 95% CI PBO | P value HCQ vs PBO | Difference adj. group means (95% CI) | ||
AUSCAN stiffness | 4.8 | 4.2 | 5.4 | 5.0 | 4.4 | 5.5 | 0.62 | −0.2 (−1.0 to 0.6) |
Tender joint counts | 6.4 | 4.8 | 7.9 | 7.1 | 5.4 | 8.7 | 0.49 | −0.7 (−2.6 to 1.3) |
Swollen joint counts | 2.0 | 1.3 | 2.7 | 2.1 | 1.4 | 2.7 | 0.93 | 0.0 (−1.0 to 0.9) |
Periarticular soft tissue oedema | 1.2 | 0.7 | 1.6 | 1.3 | 0.8 | 1.9 | 0.61 | −0.2 (−0.8 to 0.5) |
ESR in mm/hour | 8.2 | 6.9 | 9.6 | 11.7 | 10.1 | 13.5 | <0.01 | −3.5 (−6.9 to −1.3) |
CRP in mg/L | 2.1 | 1.6 | 2.6 | 2.6 | 2.1 | 3.2 | 0.15 | −0.5 (−2.4 to 1.2) |
HAQ | 0.9 | 0.8 | 1.0 | 0.8 | 0.7 | 0.9 | 0.46 | 0.1 (−0.1 to 0.2) |
Physician global | 3.2 | 2.8 | 3.6 | 3.5 | 3.0 | 3.9 | 0.39 | −0.3 (−0.9 to 0.3) |
Patient global | 4.5 | 3.9 | 5.1 | 5.2 | 4.6 | 5.8 | 0.14 | −0.6 (−1.4 to 0.2) |
SF-SACRAH | 4.00 | 3.5 | 4.5 | 4.3 | 3.8 | 4.7 | 0.38 | −0.3 (−1.0 to 0.4) |
SF-36 mental | 48.8 | 46.6 | 51.0 | 50.8 | 48.7 | 52.8 | 0.22 | −1.9 (−5.0 to 1.2) |
SF-36 physical | 39.8 | 38.0 | 41.6 | 39.9 | 38.2 | 41.6 | 0.95 | −0.1 (−2.6 to 2.4) |
Morning stiffness in minutes | 30.2 | 24.0 | 36.3 | 16.3 | 10.3 | 22.3 | 0.001 | 13.9 (5.3 to 22.5) |
By means of analysis of covariance baseline adjusted mean values at week 52, baseline adjusted mean differences and their corresponding 95% CI were calculated.
Adj, adjusted; AUSCAN, Australian Canadian Hand Osteoarthritis Index; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; HCQ, hydroxychloroquine; PBO, placebo; SF-36, 36 Item Short Form Health Survey; SF-SACRAH, Score for Assessment and Quantification of Chronic Rheumatic Affections of the Hands.