Radiographic outcome week 52
| Outcome | Adj. mean HCQ | 95% CI HCQ | Adj. mean PBO | 95% CI PBO | P value | Difference adj. group means (95% CI) | ||
| Kallman total score | 47.1 | 46.0 | 48.2 | 46.8 | 45.7 | 47.8 | 0.71 | 0.3 (−1.2 to 1.9) |
| Erosion score | 5.8 | 5.6 | 6.1 | 5.4 | 5.2 | 5.7 | 0.02 | 0.4 (0.1 to 0.8) |
| Osteophytes | 14.7 | 14.3 | 15.0 | 14.7 | 14.4 | 15.1 | 0.56 | −0.1 (−0.6 to 0.5) |
| Joint space narrowing | 17.9 | 17.4 | 18.3 | 17.9 | 17.5 | 18.3 | 0.96 | 0.0 (−0.7 to 0.6) |
| Lateral deformity | 2.6 | 2.4 | 2.7 | 2.6 | 2.4 | 2.7 | 0.95 | 0.0 (−0.2 to 0.2) |
| Subchondral cysts | 3.7 | 3.3 | 4.0 | 3.8 | 3.5 | 4.2 | 0.25 | −0.2 (−0.6 to 0.3) |
| Sclerosis | 2.4 | 2.1 | 2.7 | 2.3 | 2.1 | 2.6 | 0.44 | 0.1 (−0.3 to 0.5) |
The Kallman score assesses osteophytes (0–3) and lateral deformity (0–1) in 20 joints, joint space narrowing (0–3), subchondral sclerosis (0–1) and subchondral cysts (0–1), in 22 joints and erosions (0–1) in 18 joints resulting in a possible score range between 0 and 198. By means of analysis of covariance baseline adjusted mean values at week 52 and their corresponding 95% CI were calculated.
HCQ, hydroxychloroquine; PBO, placebo.