Global cognitive function | Learningandmemory | Executive function andcomplex attention | Psychomotor speed | |||||
B | (95% CI) | B | (95% CI) | B | (95% CI) | B | (95% CI) | |
All patients (n=151) | ||||||||
Total brain volume | 0.00* | 0.00 to 0.01 | 0.00* | 0.00 to 0.01 | 0.00* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 |
Grey matter volume | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 |
White matter volume | 0.00 | −0.00 to 0.01 | 0.00* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 |
WMH volume* | −0.05 | −0.18 to 0.09 | −0.07 | −0.18 to 0.05 | −0.11 | −0.24 to 0.01 | −0.14* | −0.32 to −0.02 |
Minor/non-NPSLE (n=115) | ||||||||
Total brain volume | 0.00 | −0.00 to 0.01 | 0.00* | 0.00 to 0.01 | 0.00* | 0.00 to 0.01 | 0.00* | 0.00 to 0.01 |
Grey matter volume | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 |
White matter volume | 0.00 | −0.00 to 0.01 | 0.00 | −0.00 to 0.01 | 0.01* | 0.00 to 0.01 | 0.01* | 0.00 to 0.01 |
WMH volume* | 0.02 | −0.14 to 0.17 | −0.03 | −0.17 to 0.10 | −0.07 | −0.22 to 0.07 | −0.07 | −0.22 to 0.07 |
Inflammatory NPSLE (n=24) | ||||||||
Total brain volume | 0.00 | −0.01 to 0.02 | 0.01 | −0.00 to 0.02 | 0.01 | −0.01 to 0.01 | 0.01 | −0.00 to 0.02 |
Grey matter volume | 0.00 | −0.01 to 0.02 | 0.00 | −0.01 to 0.02 | 0.00 | −0.01 to 0.02 | 0.01 | −0.01 to 0.02 |
White matter volume | −0.01 | −0.02 to 0.03 | 0.01 | −0.00 to 0.03 | 0.02 | −0.00 to 0.04 | 0.02* | 0.00 to 0.03 |
WMH volume* | −0.14 | −0.49 to 0.21 | −0.11 | −0.43 to 0.20 | −0.22 | −0.52 to 0.08 | −0.36* | −0.60 to 0.12 |
Ischaemic NPSLE (n=12) | ||||||||
Total brain volume | 0.00 | −0.02 to 0.01 | 0.00 | −0.02 to 0.01 | 0.00 | −0.01 to 0.01 | 0.00 | −0.01 to 0.01 |
Grey matter volume | 0.00 | −0.03 to 0.02 | 0.00 | −0.03 to 0.03 | −0.00 | −0.02 to 0.02 | 0.00 | −0.01 to 0.02 |
White matter volume | 0.00 | −0.01 to 0.02 | 0.00 | −0.04 to 0.03 | 0.00 | −0.02 to 0.03 | 0.00 | −0.01 to 0.03 |
WMH volume* | −0.02 | −1.00 to 0.96 | −0.12 | −1.14 to 0.89 | −0.28 | −1.08 to 0.52 | −0.21 | −0.86 to 0.44 |
These data represent B’s and 95% CI’s corrected for age, sex and intracranial volume. *p≤0.05. The B’s shown represent how much the (transformed) Z-score of a cognitive domain changes when the brain volume changes one unit.
*WMH volume: expected negative association with cognitive function, whereas all other domains are expected to have a positive association.
NPSLE, neuropsychiatric systemic lupus erythematosus.;