Table 1

Serum cytokine concentrations among patients with Modic change (MC1), MC2 and healthy controls

Concentrations (pg/mL)Pairwise comparison
P valuesP valuesP values
CytokineMC1MC2HCMC1 versus HCMC2 versus HCMC1 versus MC2
IL-1β0.56±0.390.48±0.710.41±0.470.571.01.0
IL-22.08±0.242.06±0.251.91±0.290.0050.031.0
IL-43.35±0.333.35±0.333.19±0.330.070.111.0
IL-61.42±0.301.45±0.391.14±0.32<0.001<0.0011.0
IL-82.09±0.332.08±0.312.00±0.340.480.681.0
IL-102.10±0.232.06±0.231.96±0.330.040.221.0
IL-165.60±0.345.58±0.275.24±0.25<0.001<0.0011.0
IFN-γ2.58±0.222.54±0.242.42±0.220.0030.071.0
TNF-α2.87±0.212.81±0.252.77±0.430.311.01.0
MIF6.55±1.116.82±1.335.59±0.53<0.001<0.0010.69
GM-CSF2.47±0.792.30±0.882.20±1.100.461.01.0
CCL13.09±0.193.12±0.153.00±0.290.110.041.0
CCL24.14±0.394.15±0.404.03±0.350.400.361.0
CCL31.77±0.331.76±0.291.64±0.300.100.171.0
CCL74.07±0.244.05±0.243.93±0.230.020.061.0
CCL83.67±0.473.72±0.463.57±0.490.830.421.0
CCL113.68±0.253.70±0.293.58±0.240.170.071.0
CCL134.38±0.474.50±0.544.31±0.441.00.210.76
CCL157.95±0.327.80±0.647.70±0.390.030.840.48
CCL174.90±0.665.06±0.694.72±0.731.00.080.57
CCL194.66±0.374.62±0.364.46±0.310.020.081.0
CCL201.67±0.501.61±0.391.31±0.510.0010.011.0
CCL218.76±0.278.76±0.328.62±0.270.060.081.0
CCL226.69±0.346.74±0.366.45±0.410.0050.0021.0
CCL235.83±0.615.91±0.585.73±0.391.00.381.0
CCL246.20±0.636.22±0.646.12±0.611.01.01.0
CCL255.47±0.275.46±0.215.30±0.320.010.021.0
CCL262.63±0.392.63±0.322.40±0.420.010.021.0
CCL276.95±0.396.91±0.316.51±0.52<0.001<0.0011.0
CXCL15.08±0.275.09±0.285.03±0.241.00.911.0
CXCL25.38±0.665.62±0.615.52±0.550.801.00.22
CXCL63.58±0.403.60±0.413.42±0.310.140.101.0
CXCL95.21±0.545.11±0.465.04±0.630.381.01.0
CXCL105.19±0.435.23±0.525.10±0.551.00.581.0
CXCL112.86±0.492.84±0.502.76±0.621.01.01.0
CXCL127.67±0.307.67±0.277.57±0.350.370.471.0
CXCL133.05±0.383.00±0.272.81±0.410.0060.051.0
CXCL166.12±0.296.17±0.275.96±0.420.070.011.0
CX3CL14.77±0.204.65±0.194.44±0.26<0.001<0.0010.06
  • Mean concentrations and SD of log-transformed serum cytokines among patients with MC1, MC2 and healthy controls. Comparative analyses (MC1 vs MC2 vs healthy controls) by analysis of variance. Significant p values after correction for multiple comparisons are in bold.

  • HC, Healthy controls; MIF, macrophage migration inhibitory factor.