Gene | Name | Function | Mean (IL1) | Mean (IL1 +ibu) | FC | adj. P |
PPARG | Peroxisome proliferator activated receptor gamma | Carbohydrate and lipid metabolism, inflammation | 0.3 | 0.9 | 2.87 | 5.0E−06 |
UMODL1 | Uromodulin like 1 | Regulation of apoptosis? | 0.3 | 0.7 | 2.39 | 0.0011 |
XIRP1 | Xin actin binding repeat containing 1 | Actin binding | 5.7 | 13.4 | 2.38 | < 1.0E−06 |
DACT1 | Dishevelled binding antagonist of beta catenin 1 | Regulation of cell cycle and tissue development | 4 | 8.4 | 2.1 | < 1.0E−06 |
CSF2/GM-CSF | Colony stimulating factor 2=Granulocyte-macrophage colony stimulating factor | Leucocyte differentiation, immune response | 5.2 | 11.2 | 2.09 | < 1.0E−06 |
PPARGC1B | PPARG coactivator 1 beta | Regulation of transcription | 0.4 | 0.8 | 2.07 | 0.00024 |
FAM186B | Family with sequence similarity 186 member B | ? | 0.4 | 0.7 | 1.92 | 0.0035 |
SOX17 | SRY-box 17 | Cell proliferation, tissue development | 3.5 | 6.8 | 1.91 | < 1.0E−06 |
MTSS1 | MTSS1, I-BAR domain containing | Cell adhesion | 6.9 | 12.6 | 1.9 | < 1.0E−06 |
AKAP6 | A-kinase anchoring protein 6 | Regulation of cell proliferation, cAMP signalling | 2.1 | 3.9 | 1.89 | < 1.0E−06 |
PDE5A | Phosphodiesterase 5A | Regulation of NO signalling | 1.2 | 2.3 | 1.85 | 7.0E−06 |
RGS2 | Regulator of G protein signalling 2 | Regulation of G protein signalling | 52.1 | 95.9 | 1.85 | < 1.0E−06 |
CAMK2A | Calcium/calmodulin dependent protein kinase II alpha | Wnt and TGFβ signalling, NF-κB activation | 1.8 | 3.3 | 1.81 | < 1.0E−06 |
MAP1LC3C | Microtubule associated protein 1 light chain 3 gamma | Autophagy | 0.7 | 1.2 | 1.79 | 3.3E−05 |
NRG1 | Neuregulin 1 | Cell differentiation, signal transduction | 0.7 | 1.3 | 1.78 | 5.9E−05 |
SELE | Selectin E | Inflammation | 41.3 | 73.5 | 1.78 | < 1.0E−06 |
FCRLA | Fc receptor like A | Immunoglobulin binding | 4.2 | 7.4 | 1.76 | < 1.0E−06 |
DENND3 | DENN domain containing 3 | Autophagy | 14.6 | 25.3 | 1.75 | < 1.0E−06 |
FCRLB | Fc receptor like B | Immunoglobulin binding | 0.8 | 1.4 | 1.73 | 3.3E−05 |
MOXD1 | Monooxygenase DBH like 1 | Monoamine metabolism | 123.1 | 210.3 | 1.72 | < 1.0E−06 |
SPNS2 | Sphingolipid transporter 2 | Lipid transport | 2.4 | 4.0 | 1.72 | < 1.0E−06 |
PODXL | Podocalyxin like | Cell adhesion | 11.2 | 19.0 | 1.71 | < 1.0E−06 |
RP1 | RP1, axonemal microtubule associated | ? | 0.4 | 0.6 | 1.67 | 0.023 |
IDO1 | Indoleamine 2,3-dioxygenase 1 | Modulation of inflammation and cartilage development | 1.3 | 2.1 | 1.65 | 0.0012 |
SCUBE3 | Signal peptide, CUB domain and EGF like domain containing 3 | TGFβ signalling | 42.5 | 72.5 | 1.64 | < 1.0E−06 |
KCNJ15 | Potassium voltage-gated channel subfamily J member 15 | Potassium transport | 1.3 | 2.2 | 1.63 | 1.0E−06 |
SERPINE1 | Serpin family E member 1 | Inhibition of proteolysis | 455.9 | 748.6 | 1.62 | < 1.0E−06 |
PSD2 | Pleckstrin and Sec7 domain containing 2 | ? | 0.4 | 0.6 | 1.62 | 0.035 |
LINGO1 | Leucine rich repeat and Ig domain containing 1 | ? | 1.9 | 3.1 | 1.61 | < 1.0E−06 |
AKNAD1 | AKNA domain containing 1 | ? | 0.6 | 1.0 | 1.60 | 0.0048 |
STRA6 | Stimulated by retinoic acid 6 | Retinol and adipokine binding | 1.9 | 2.9 | 1.59 | 0.00058 |
ITGAX | Integrin subunit alpha X | Cell adhesion | 11.0 | 17.4 | 1.58 | < 1.0E−06 |
KCNN3 | Potassium calcium-activated channel subfamily N member 3 | Potassium transport | 2.8 | 4.3 | 1.58 | < 1.0E−06 |
ICAM5 | Intercellular adhesion molecule 5 | Cell adhesion | 4.5 | 7.2 | 1.58 | < 1.0E−06 |
FGD4 | FYVE, RhoGEF and PH domain containing 4 | Cytoskeleton organisation | 21.9 | 34.0 | 1.57 | < 1.0E−06 |
KCNN4 | Potassium calcium-activated channel subfamily N member 4 | Potassium transport | 6.4 | 10.0 | 1.57 | < 1.0E−06 |
LRRC55 | Leucine rich repeat containing 55 | Potassium transport | 0.8 | 1.3 | 1.56 | 0.0013 |
CXCR3 | C-X-C motif chemokine receptor 3 | Inflammation | 0.7 | 1.1 | 1.55 | 0.017 |
CD24 | CD24 molecule | Wnt and MAPK signalling, regulation of inflammation | 5.4 | 8.5 | 1.55 | < 1.0E−06 |
FGR | FGR proto-oncogene, Src family tyrosine kinase | PI3K-Akt signalling, regulation of inflammation | 3.4 | 5.2 | 1.54 | < 1.0E−06 |
PEG10 | Paternally expressed 10 | Inhibition of TGFβ signalling | 23.9 | 36.4 | 1.54 | < 1.0E−06 |
SIGLEC15 | Sialic acid binding Ig like lectin 15 | Regulation of bone resorbtion | 1.6 | 2.4 | 1.54 | 0.00024 |
CPNE2 | Copine 2 | Bone erosion | 18.7 | 28.9 | 1.54 | < 1.0E−06 |
WNK4 | WNK lysine deficient protein kinase 4 | Ion transport | 4.6 | 7.0 | 1.53 | < 1.0E−06 |
RTL3 | Retrotransposon Gag like 3 | Regulation of collagen production | 3.3 | 5.0 | 1.53 | < 1.0E−06 |
RGS3 | Regulator of G protein signalling 3 | Inhibition of MAPK signalling | 65.1 | 99.2 | 1.52 | < 1.0E−06 |
AOC2 | Amine oxidase, copper containing 2 | Amine metabolism | 68.0 | 102.3 | 1.51 | < 1.0E−06 |
IL10RA | Interleukin 10 receptor subunit alpha | Regulation of inflammation | 1.0 | 1.6 | 1.51 | 0.0018 |
RGS16 | Regulator of G protein signalling 16 | ? | 60.1 | 90.0 | 1.51 | < 1.0E−06 |
PCDH17 | Protocadherin 17 | Cell adhesion | 0.9 | 1.4 | 1.51 | 0.028 |
GPR158 | G protein-coupled receptor 158 | ? | 1.3 | 1.9 | 1.50 | 0.00017 |
IL23A | Interleukin 23 subunit alpha | Inflammation | 15.2 | 4.7 | −3.24 | < 1.0E−06 |
HAS1 | Hyaluronan synthase 1 | Extracellular matrix production | 0.8 | 0.3 | −2.77 | < 1.0E−06 |
IGFBP4 | Insulin-like growth factor binding protein 4 | Cell proliferation and metabolism | 213.8 | 79.7 | −2.73 | < 1.0E−06 |
IL6 | Interleukin 6 | Inflammation | 958.4 | 403.8 | −2.49 | < 1.0E−06 |
PDE3A | Phosphodiesterase 3A | Lipid metabolism | 0.9 | 0.3 | −2.48 | 0.00013 |
STAT4 | Signal transducer and activator of transcription 4 | Inflammation, regulation of cell proliferation | 2.5 | 1.0 | −2.36 | < 1.0E−06 |
PCSK1 | Proprotein convertase subtilisin/kexin type 1 | Metabolism | 7.2 | 3.2 | −2.19 | < 1.0E−06 |
ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif 6 | Extracellular matrix catabolism | 10.5 | 4.9 | −2.18 | < 1.0E−06 |
HAL | Histidine ammonia-lyase | Histidine catabolism | 1.7 | 0.8 | −2.12 | < 1.0E−06 |
DNAH17 | Dynein axonemal heavy chain 17 | Cytoskeleton component | 1.0 | 0.5 | −2.06 | 2.00E−06 |
CSF3 | Colony stimulating factor 3 | Inflammation, regulation of cell proliferation | 19.8 | 9.9 | −2.02 | < 1.0E−06 |
AREG | Amphiregulin | EGF signalling, regulation of cell proliferation | 2.3 | 1.2 | −2.01 | < 1.0E−06 |
CA12 | Carbonic anhydrase 12 | Acidity regulation, Regulation of proliferation | 20.9 | 10.5 | −2.00 | < 1.0E−06 |
INSC | Inscuteable homolog (Drosophila) | Cell differentiation | 0.6 | 0.3 | −1.98 | 0.0011 |
KCNE5 | Potassium voltage-gated channel subfamily E regulatory subunit 5 | Regulation of potassium transport | 1.3 | 0.6 | −1.94 | 6.00E−06 |
LDB2 | LIM domain binding 2 | Regulation of transcription | 0.5 | 0.3 | −1.92 | 0.005098 |
DOK6 | Docking protein 6 | ? | 0.9 | 0.5 | −1.80 | 0.000598 |
DAW1 | Dynein assembly factor with WD repeats 1 | Dynein assembly | 0.9 | 0.5 | −1.78 | 0.000565 |
TMEM71 | Transmembrane protein 71 | ? | 1.8 | 1.0 | −1.77 | 2.00E−06 |
MAMSTR | MEF2 activating motif and SAP domain containing transcriptional regulator | Regulation of transcription | 0.5 | 0.3 | −1.72 | 0.021819 |
KNDC1 | Kinase non-catalytic C-lobe domain containing 1 | ? | 0.8 | 0.5 | −1.70 | 0.002773 |
EFHC2 | EF-hand domain containing 2 | Cell proliferation | 0.8 | 0.5 | −1.69 | 0.004747 |
MEX3A | Mex-3 RNA binding family member A | PI3K-Akt signalling | 0.9 | 0.5 | −1.69 | 0.001905 |
TGFBI | Transforming growth factor beta induced | ECM organisation, chondrocyte differentiation | 127.8 | 80.7 | −1.64 | < 1.0E−06 |
C3AR1 | Complement C3a receptor 1 | Inflammation | 3.5 | 2.2 | −1.63 | < 1.0E−06 |
EFEMP1 | EGF containing fibulin like extracellular matrix protein 1 | Inhibition of chondrocyte differentiation | 72.6 | 45.4 | −1.63 | < 1.0E−06 |
NAMPT | Nicotinamide phosphoribosyltransferase / visfatin | Cartilage catabolism | 596.1 | 368.8 | −1.60 | < 1.0E−06 |
FOXF1 | Forkhead box F1 | Morphogenesis | 1.2 | 0.8 | −1.60 | 0.000928 |
AVPI1 | Arginine vasopressin induced 1 | MAPK signalling | 39.7 | 24.8 | −1.60 | < 1.0E−06 |
SEMA3A | Semaphorin 3A | Regulation of inflammation and apoptosis | 98.0 | 61.6 | −1.59 | < 1.0E−06 |
STC1 | Stanniocalcin 1 | Regulation of cartilage development | 2.0 | 1.3 | −1.59 | 0.002967 |
TSKU | Tsukushi, small leucine rich proteoglycan | ? | 14.9 | 9.4 | −1.58 | < 1.0E−06 |
SMOC1 | SPARC related modular calcium binding 1 | ECM organisation | 199.0 | 126.1 | −1.57 | < 1.0E−06 |
ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | Cell adhesion, inhibition of Akt signalling | 12.5 | 8.0 | −1.56 | < 1.0E−06 |
BEND5 | BEN domain containing 5 | Negative regulation of transcription | 0.9 | 0.6 | −1.54 | 0.01673 |
EPB41L3 | Erythrocyte membrane protein band 4.1 like 3 | Cortical cytoskeleton organisation | 34.6 | 22.5 | −1.53 | < 1.0E−06 |
EPB41L4B | Erythrocyte membrane protein band 4.1 like 4B | Regulation of cell adhesion and gene expression | 2.8 | 1.8 | −1.53 | 0.000106 |
ACSL4 | Acyl-CoA synthetase long-chain family member 4 | Lipid metabolism | 428.1 | 280.7 | −1.52 | < 1.0E−06 |
NR4A2 | Nuclear receptor subfamily 4 group A member 2 | Wnt signalling, regulation of apoptosis | 19.8 | 13.1 | −1.51 | < 1.0E−06 |
PID1 | Phosphotyrosine interaction domain containing 1 | Oxidative metabolism | 285.1 | 190.6 | −1.51 | < 1.0E−06 |
RSPO3 | R-spondin 3 | Wnt signalling, morphogenesis | 82.9 | 53.8 | −1.50 | < 1.0E−06 |
Red = upregulated genes; blue = downregulated genes.
adj. P, False discovery rate (FDR) -adjusted P value; IL, interleukin; Mean, trimmed mean of M-values (TMM) normalized counts.