Table 2

Canonical IPA pathways significantly upregulated or downregulated (z-score ≥2.5 or ≤−2.5) by ibuprofen in the presence of IL-1β

Canonical pathwayadj. Pz-score
Integrin signalling4.37E−084.95
Actin cytoskeleton signalling0.00224.24
PI3K signalling in B lymphocytes0.000323.44
Agrin Interactions at neuromuscular junction0.00373.32
IL-8 signalling7.08E−073.29
ERK5 signalling0.00833.16
Glioblastoma multiforme signalling1.32E−063.14
Paxillin signalling4.27E−063.05
ErbB2-ErbB3 signalling0.0293.00
FcγRIIB signalling in B lymphocytes0.0253.00
Renal cell carcinoma signalling0.00163.00
Bladder cancer signalling6.31E−063.00
14-3-3-mediated signalling0.00582.89
PKCθ signalling in T lymphocytes0.0302.84
Calcium signalling0.00832.84
Thrombin signalling0.00252.83
CREB signalling in neurons0.00192.83
HGF signalling1.15E−062.83
Non-small cell lung cancer signalling0.00292.83
α-Adrenergic signalling5.37E−062.71
Endothelin-1 signalling0.00982.68
Mouse embryonic stem cell pluripotency0.00522.67
NF-κB activation by viruses0.000892.67
Macropinocytosis signalling4.27E−072.67
CXCR4 signalling0.00482.67
p70S6K signalling0.00262.67
cAMP-mediated signalling0.00342.56
ErbB4 signalling0.0142.53
Chemokine signalling0.0132.53
Actin nucleation by ARP-WASP complex0.000782.53
Regulation of cellular mechanics by calpain protease5.25E−052.53
Synaptic long-term potentiation0.000112.52
Cardiac hypertrophy signalling0.000152.50
ERK/MAPK signalling1.91E−052.50
fMLP signalling in neutrophils0.00122.50
PAK signalling0.000132.50
Rac signalling0.0262.50
IL-3 signalling0.00182.50
Acute myeloid leukaemia signalling0.00172.50
Telomerase signalling0.00112.50
Wnt/Ca+pathway5.25E−052.50
PTEN signalling0.000872.67
  • adj.P, False discovery rate (FDR) -adjusted P value; CREB, cAMP response element-binding protein; IL-1β, interleukin 1β; IPA, ingenuity pathway analysis.